Modulators of LXR

1. A compound having the following formula (II):

wherein:

n is 0 to 4;

m is 0 to 5;

R 1 is hydrogen, aralkyl or heteroarylalkyl;

R 2 is hydrogen, cyano or —R 7 —N(R 8 ) 2 ;

R 3 is haloalkyl;

each R 4 is independently halo, alkyl or haloalkyl;

each R 5 is independently selected from the group consisting of halo, nitro, alkyl, alkenyl, aryl, aralkyl, aralkenyl, haloalkyl, haloalkenyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, heteroaryl, heteroarylalkyl, —R 7 —CN, —R 7 —N(R 8 ) 2 , —R 7 —OR 8 , —R 7 —O—R 9 —C(O)OR 8 , —R 7 —C(O)R 11 , —R 7 —C(O)OR 8 , —R 7 —C(O)N(R 8 ) 2 , —R 7 —C(O)N(R 8 )OR 8 , —R 7 —C(O)N(R 8 )N(R 8 ) 2 , —R 7 —C(O)N(R 8 )—R 9 —C(O)OR 8 , —R 7 —C(S)N(R 8 ) 2 , —R 7 —N(R 8 )C(O)OR 10 , —R 7 —S(O) t R 8 (where t is 0 to 2) and —R 7 —S(O) 2 N(R 8 ) 2 ;

R 6 is —OR 7 —, a direct bond, a straight or branched alkylene chain, a straight or branched alkenylene chain or a straight or branched alkynylene chain;

each R 7 is independently selected from a direct bond, a straight or branched alkylene chain or a straight or branched alkenylene chain;

each R 8 is independently selected from hydrogen, alkyl, alkenyl, haloalkyl, haloalkenyl, aryl, aralkyl, aralkenyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, heteroaryl or heteroarylalkyl;

each R 9 is independently selected from a straight or branched alkylene chain or a straight or branched alkenylene chain;

R 10 is alkyl, aryl, aralkyl or cycloalkylalkyl; and

R 11 is hydrogen, alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, heteroaryl or heterarylalkyl;

as a stereoisomer, a mixture of stereoisomers, a racemic mixture of stereoisomers, or as a tautomer;

or as a pharmaceutically acceptable salt thereof.

2. The compound of claim 1 wherein:

n is 0 or 1;

m is 0 to 2;

R 1 is aralkyl or heteroarylalkyl;

R 2 is cyano;

R 3 is haloalkyl;

R 4 is halo, alkyl or haloalkyl;

each R 5 is independently selected from the group consisting of halo, nitro, alkyl, alkenyl, haloalkyl, heterocyclyl, heteroaryl, —R 7 —CN, —R 7 —N(R 8 ) 2 , —R 7 —OR 8 , —R 7 —O—R 9 —C(O)OR 8 , —R 7 —C(O)R 11 , —R 7 —C(O)OR 8 , —R 7 —C(O)N(R 8 ) 2 , —R 7 —C(O)N(R 8 )OR 8 , —R 7 —C(O)N(R 8 )N(R 8 ) 2 , —R 7 —C(O)N(R 8 )—R 9 —C(O)OR 8 , —R 7 —C(S)N(R 8 ) 2 , —R 7 —N(R 8 )C(O)OR 10 , —R 7 —S(O) t R 8 (where t is 0 to 2) and —R 7 —S(O) 2 N(R 8 ) 2 ;

R 6 is —OR 7 —, a direct bond, a straight or branched alkenylene chain or a straight or branched alkynylene chain;

each R 7 is independently selected from a direct bond or a straight or branched alkylene chain;

each R 8 is independently selected from hydrogen, alkyl, alkenyl, haloalkyl, haloalkenyl, aryl, aralkyl, aralkenyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, heteroaryl or heteroarylalkyl;

each R 9 is a straight or branched alkylene chain optionally substituted by aryl or heteroaryl;

R 10 is alkyl, aryl, aralkyl or cycloalkylalkyl; and

R 11 is hydrogen, alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, heteroaryl or heterarylalkyl.

3. The compound of claim 2 wherein R 6 is —OR 7 —.

4. The compound of claim 3 wherein R 1 is aralkyl optionally substituted with one or more substituents independently selected from alkyl, halo or haloalkyl.

5. The compound of claim 4 wherein

n is 0 or 1;

m is 0 to 2;

R 2 is cyano;

R 3 is trifluoromethyl;

R 4 is methyl, 1-methylethyl or chloro;

each R 5 is independently selected from the group consisting of halo, alkyl, alkenyl or haloalkyl.

6. The compound of claim 5 wherein each R 5 is independently selected from chloro, bromo, fluoro, methyl, ethyl, 1-methylethyl, 1,1-dimethylethyl, ethenyl or trifluoromethyl.

7. The compound of claim 6 selected from the group consisting of the following:

1-(2,4-Dimethyl-benzyl)-6-[4-(3-isopropyl-phenoxy)-3-methyl-phenyl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile;

6-[4-(4-tert-Butyl-phenoxy)-3-methyl-phenyl]-1-(2,4-dimethyl-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile;

1-(2,4-Dimethyl-benzyl)-6-[4-(4-fluoro-phenoxy)-3-methyl-phenyl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile;

1-(2,4-Dimethyl-benzyl)-6-[4-(2,4-dimethyl-phenoxy)-3-methyl-phenyl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile;

1-(2,4-Dimethyl-benzyl)-6-[4-(2,5-dimethyl-phenoxy)-3-methyl-phenyl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile;

1-(2,4-Dimethyl-benzyl)-6-[4-(2,6-dimethyl-phenoxy)-3-methyl-phenyl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile;

6-[4-(2-Chloro-phenoxy)-3-methyl-phenyl]-1-(2,4-dimethyl-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile;

6-[4-(3-Chloro-phenoxy)-3-methyl-phenyl]-1-(2,4-dimethyl-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile;

1-(2,4-Dimethyl-benzyl)-6-[3-methyl-4-(2-trifluoromethyl-phenoxy)-phenyl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile;

1-(2,4-Dimethyl-benzyl)-6-[3-methyl-4-(3-trifluoromethyl-phenoxy)-phenyl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile;

6-[4-(3-Bromo-phenoxy)-phenyl]-1-(2,4-dimethyl-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile;

6-[4-(4-Bromo-phenoxy)-phenyl]-1-(2,4-dimethyl-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile;

6-[4-(3-Benzyloxy-phenoxy)-phenyl]-1-(2,4-dimethyl-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile;

1-(2,4-Dimethyl-benzyl)-6-[4-(2,4-dimethyl-phenoxy)-phenyl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile;

6-[4-(3,5-Bis-trifluoromethyl-phenoxy)-phenyl]-1-(2,4-dimethyl-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile;

6-(4-Benzyloxy-phenyl)-1-(2,4-dichloro-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile;

1-(2,4-Dichloro-benzyl)-2-oxo-6-(4-phenoxy-phenyl)-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile;

1-(2,4-Difluoro-benzyl)-2-oxo-6-(4-phenoxy-phenyl)-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile;

1-(2-Chloro-4-fluoro-benzyl)-2-oxo-6-(4-phenoxy-phenyl)-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile;

6-(4-Benzyloxy-phenyl)-1-(2-chloro-4-fluoro-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile;

1-(2,4-Dichloro-benzyl)-2-oxo-4-pentafluoroethyl-6-(4-phenoxy-phenyl)-1,2-dihydro-pyridine-3-carbonitrile;

1-(2,4-Dimethyl-benzyl)-6-(3-isopropyl-4-phenoxy-phenyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile;

1-(2,4-Dimethyl-benzyl)-6-(3-isopropyl-4-o-tolyloxy-phenyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile;

1-(2,4-Dimethyl-benzyl)-6-[4-(2-ethyl-phenoxy)-3-isopropyl-phenyl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile;

1-(2,4-Dimethyl-benzyl)-6-[4-(2,5-dimethyl-phenoxy)-3-isopropyl-phenyl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile;

1-(2,4-Dimethyl-benzyl)-6-[4-(2,4-dimethyl-phenoxy)-3-isopropyl-phenyl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile;

1-(2,4-Dimethyl-benzyl)-6-[4-(3,4-dimethyl-phenoxy)-3-isopropyl-phenyl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile;

1-(2,4-Dimethyl-benzyl)-6-(3-isopropyl-4-m-tolyloxy-phenyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile;

1-(2,4-Dimethyl-benzyl)-6-[3-isopropyl-4-(3-isopropyl-phenoxy)-phenyl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile;

1-(2,4-Dimethyl-benzyl)-6-[3-isopropyl-4-(4-isopropyl-phenoxy)-phenyl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile;

1-(2,4-Dimethyl-benzyl)-6-(3-isopropyl-4-p-tolyloxy-phenyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile;

6-[4-(4-tert-Butyl-phenoxy)-3-isopropyl-phenyl]-1-(2,4-dimethyl-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile;

1-(2,4-Dimethyl-benzyl)-6-[3-isopropyl-4-(4-vinyl-phenoxy)-phenyl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile;

1-(2,4-Dimethyl-benzyl)-6-[4-(4-ethyl-2-methyl-phenoxy)-3-methyl-phenyl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile;

1-(2,4-Dimethyl-benzyl)-6-[4-(4-ethyl-2-methyl-phenoxy)-3-isopropyl-phenyl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile;

1-(2,4-Dimethyl-benzyl)-6-[4-(2-ethyl-4-methyl-phenoxy)-3-methyl-phenyl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile;

1-(2,4-Dimethyl-benzyl)-6-[4-(2-ethyl-4-methyl-phenoxy)-3-isopropyl-phenyl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile;

6-(4-Benzyloxy-3-chloro-phenyl)-1-(2,4-difluoro-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile;

6-[3-Chloro-4-(4-fluoro-phenoxy)-phenyl]-1-(2,4-difluoro-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; and

1-(2,4-Difluoro-benzyl)-6-[4-(4-fluoro-phenoxy)-phenyl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile,

or a pharmaceutically acceptable salt of any of the foregoing.

8. The compound of claim 4 wherein:

n is 0 or 1;

m is 1 or 2;

R 2 is cyano;

R 3 is trifluoromethyl;

R 4 is methyl, 1-methylethyl or chloro;

each R 5 is independently selected from the group consisting of haloalkyl, —R 7 —CN, —R 7 —N(R 8 ) 2 , —R 7 —OR 8 and R 7 —O—R 9 —C(O)OR 8

each R 7 is independently selected from a direct bond or methylene chain;

each R 8 is independently selected from hydrogen, alkyl, aryl and aralkyl; and

R 9 is a methylene chain.

9. The compound of claim 8 selected from the group consisting of the following:

6-[4-(4-Dimethylamino-phenoxy)-3-methyl-phenyl]-1-(2,4-dimethyl-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile;

1-(2,4-Dimethyl-benzyl)-6-[4-(4-methoxy-phenoxy)-3-methyl-phenyl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile;

6-[4-(3-Cyano-phenoxy)-3-methyl-phenyl]-1-(2,4-dimethyl-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile;

6-[4-(4-Benzyloxy-phenoxy)-3-methyl-phenyl]-1-(2,4-dimethyl-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile;

6-[4-(3-Benzyloxy-phenoxy)-3-methyl-phenyl]-1-(2,4-dimethyl-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile;

6-[4-(3-Cyano-phenoxy)-phenyl]-1-(2,4-dimethyl-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile;

6-[4-(4-Cyano-phenoxy)-phenyl]-1-(2,4-dimethyl-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile;

6-[4-(4-Dimethylamino-phenoxy)-phenyl]-1-(2,4-dimethyl-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile;

1-(2,4-Dimethyl-benzyl)-6-[4-(4-hydroxy-phenoxy)-phenyl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile;

1-(2,4-Dimethyl-benzyl)-6-[4-(3-hydroxy-phenoxy)-phenyl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile;

1-(2,4-Dimethyl-benzyl)-6-[4-(4-hexyloxy-phenoxy)-phenyl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile;

1-(2,4-Dimethyl-benzyl)-6-{4-[4-(3-methyl-butoxy)-phenoxy]-phenyl}-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile;

1-(2,4-Dimethyl-benzyl)-6-[4-(3-hexyloxy-phenoxy)-phenyl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile;

1-(2,4-Dimethyl-benzyl)-6-{4-[3-(3-methyl-butoxy)-phenoxy]-phenyl}-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile;

(3-{4-[5-Cyano-1-(2,4-dimethyl-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-phenoxy}-phenoxy)-acetic acid benzyl ester;

(4-{4-[5-Cyano-1-(2,4-dimethyl-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-phenoxy}-phenoxy)-acetic acid benzyl ester;

1-(2,4-Dimethyl-benzyl)-2-oxo-6-[4-(4-phenylamino-phenoxy)-phenyl]-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile;

6-[4-(4-Benzylamino-phenoxy)-phenyl]-1-(2,4-dimethyl-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile;

1-(2,4-Dimethyl-benzyl)-6-[4-(3-hydroxymethyl-phenoxy)-phenyl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile;

6-[4-(3-Benzyloxy-phenoxy)-3-isopropyl-phenyl]-1-(2,4-dimethyl-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile;

6-[4-(4-Benzyloxy-phenoxy)-3-isopropyl-phenyl]-1-(2,4-dimethyl-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile;

1-(2,4-Difluoro-benzyl)-6-[4-(3-hydroxy-phenoxy)-phenyl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile;

1-(2,4-Difluoro-benzyl)-6-[4-(4-hydroxy-phenoxy)-phenyl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; and

6-[4-(3-Cyano-4-trifluoromethyl-phenoxy)-phenyl]-1-(2,4-difluoro-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile,

or a pharmaceutically acceptable salt of any of the foregoing.

10. The compound of claim 4 wherein:

n is 0 or 1;

m is 1 or 2;

R 2 is cyano;

R 3 is trifluoromethyl;

R 4 is methyl, 1-methylethyl or chloro;

each R 5 is independently selected from the group consisting of heteroaryl, —R 7 —OR 8 , —R 7 —C(O)R 11 , —R 7 —C(O)OR 8 , —R 7 —C(O)N(R 8 ) 2 , —R 7 —C(O)N(R 8 )OR 8 , —R 7 —C(O)N(R 8 )N(R 8 ) 2 , —R 7 —C(O)N(R 8 )—R 9 —C(O)OR 8 , —R 7 —C(S)N(R 8 ) 2 and —R 7 —S(O) t R 8 (where t is 0 to 2);

each R 7 is independently selected from a direct bond or a straight or branched alkylene chain;

each R 8 is independently selected from hydrogen, alkyl, haloalkyl, aryl, aralkyl, aralkenyl, cycloalkyl or heterocyclyl optionally substituted with hydroxy;

R 9 is a straight or branched alkylene chain (optionally substituted by phenyl or imidazolyl); and

R 11 is hydrogen, alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, heteroaryl or heterarylalkyl.

11. The compound of claim 10 wherein:

m is 1 or 2;

each R 5 is independently selected from —R 7 —OR 8 , —R 7 —C(O)R 11 , —R 7 —C(O)OR 8 , —R 7 —C(O)N(R 8 ) 2 , —R 7 —C(O)N(R 8 )OR 8 or —R 7 —C(O)N(R 8 )N(R 8 ) 2 ;

each R 7 is independently selected from a direct bond or methylene;

each R 8 is independently selected from hydrogen, methyl, ethyl, 1,1-dimethylethyl, benzyl, 2-phenylethyl, cyclohexyl or piperidinyl optionally substituted by hydroxy; and

R 11 is hydrogen, alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, heteroaryl or heterarylalkyl.

12. The compound of claim 11 selected from the group consisting of the following:

4-{4-[5-Cyano-1-(2,4-dimethyl-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-2-methyl-phenoxy}-benzoic acid methyl ester;

3-{4-[5-Cyano-1-(2,4-dimethyl-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-2-methyl-phenoxy}-benzoic acid methyl ester;

4-{4-[5-Cyano-1-(2,4-dimethyl-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-phenoxy}-benzoic acid;

3-{4-[5-Cyano-1-(2,4-dimethyl-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-phenoxy}-N-methyl-benzamide;

3-{4-[5-Cyano-1-(2,4-dimethyl-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-phenoxy}-N,N-dimethyl-benzamide;

1-(2,4-Dimethyl-benzyl)-2-oxo-6-{4-[3-(piperidine-1-carbonyl)-phenoxy]-phenyl}-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile;

1-(2,4-Dimethyl-benzyl)-6-{4-[3-(3-hydroxy-piperidine-1-carbonyl)-phenoxy]-phenyl}-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile;

N-Benzyl-3-{4-[5-cyano-1-(2,4-dimethyl-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-phenoxy}-benzamide;

3-{4-[5-Cyano-1-(2,4-dimethyl-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-phenoxy}-benzoic acid N′-phenyl-hydrazide;

3-{4-[5-Cyano-1-(2,4-dimethyl-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-phenoxy}-N-cyclopentyl-benzamide;

3-{4-[5-Cyano-1-(2,4-dimethyl-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-phenoxy}-N-methoxy-N-methyl-benzamide;

3-{4-[5-Cyano-1-(2,4-dimethyl-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-phenoxy}-N—((S)-1-phenyl-ethyl)-benzamide;

3-{4-[5-Cyano-1-(2,4-difluoro-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-phenoxy}-N,N-dimethyl-benzamide;

3-Benzyloxy-5-{4-[5-cyano-1-(2,4-dimethyl-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-phenoxy}-benzoic acid methyl ester;

3-Benzyloxy-5-{4-[5-cyano-1-(2,4-difluoro-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-phenoxy}-N,N-dimethyl-benzamide;

3-{4-[5-Cyano-1-(2,4-difluoro-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-phenoxy}-5-hydroxy-N,N-dimethyl-benzamide;

2-Benzyloxy-5-{4-[5-cyano-1-(2,4-difluoro-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-phenoxy}-N,N-dimethyl-benzamide;

5-{4-[5-Cyano-1-(2,4-difluoro-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-phenoxy}-2-hydroxy-N,N-dimethyl-benzamide;

3-{4-[5-Cyano-1-(2,4-difluoro-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-phenoxy}-N-methyl-benzamide;

N-tert-Butyl-3-{4-[5-cyano-1-(2,4-difluoro-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-phenoxy}-benzamide; and

1-(2,4-Difluoro-benzyl)-2-oxo-6-{4-[3-(piperidine-1-carbonyl)-phenoxy]-phenyl}-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile,

or a pharmaceutically acceptable salt of any of the foregoing.

13. The compound of claim 4 wherein:

n is 0 or 1;

m is 1 or 2;

R 2 is cyano;

R 3 is trifluoromethyl;

R 4 is methyl, 1-methylethyl or chloro;

each R 5 is independently selected from the group consisting of heteroaryl, —R 7 —C(O)N(R 8 )—R 9 —C(O)OR 8 , —R 7 —C(S)N(R 8 ) 2 and —R 7 —S(O) t R 8 (where t is 0 to 2);

each R 7 is independently selected from a direct bond or a straight or branched alkylene chain;

each R 8 is independently selected from hydrogen or alkyl, haloalkyl, aryl, aralkyl, aralkenyl, cycloalkyl or heterocyclyl; and

R 9 is a straight or branched alkylene chain (optionally substituted by phenyl or imidazolyl).

14. The compound of claim 13 wherein:

n is 0 or 1;

m is 1;

R 2 is cyano;

R 3 is trifluoromethyl;

R 4 is chloro;

R 5 is —R 7 —C(O)N(R 8 )—R 9 —C(O)OR 8 ;

R 7 is a direct bond;

each R 8 is independently hydrogen or alkyl; and

R 9 is a straight or branched alkylene chain optionally substituted by phenyl or imidazolyl.

15. The compound of claim 14 selected from the group consisting of the following:

(S)-2-(3-{4-[5-Cyano-1-(2,4-dimethyl-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-phenoxy}-benzoylamino)-propionic acid methyl ester;

(R)-2-(3-{4-[5-Cyano-1-(2,4-dimethyl-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-phenoxy}-benzoylamino)-propionic acid methyl ester;

(S)-2-(3-{4-[5-Cyano-1-(2,4-dimethyl-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-phenoxy}-benzoylamino)-3-methyl-butyric acid methyl ester;

(R)-2-(3-{4-[5-Cyano-1-(2,4-dimethyl-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-phenoxy}-benzoylamino)-3-methyl-butyric acid methyl ester;

(S)-2-(3-{4-[5-Cyano-1-(2,4-dimethyl-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-phenoxy}-benzoylamino)-4-methyl-pentanoic acid methyl ester;

(R)-2-(3-{4-[5-Cyano-1-(2,4-dimethyl-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-phenoxy}-benzoylamino)-4-methyl-pentanoic acid methyl ester;

(S)-2-(3-{4-[5-Cyano-1-(2,4-dimethyl-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-phenoxy}-benzoylamino)-3-phenyl-propionic acid methyl ester;

(R)-2-(3-{4-[5-Cyano-1-(2,4-dimethyl-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-phenoxy}-benzoylamino)-3-phenyl-propionic acid methyl ester;

(S)-2-(3-{4-[5-Cyano-1-(2,4-dimethyl-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-phenoxy}-benzoylamino)-3-(1H-imidazol-4-yl)-propionic acid methyl ester;

(R)-2-(3-{4-[5-Cyano-1-(2,4-dimethyl-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-phenoxy}-benzoylamino)-3-(1H-imidazol-4-yl)-propionic acid methyl ester;

(S)-(3-{4-[5-Cyano-1-(2,4-dimethyl-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-phenoxy}-benzoylamino)-phenyl-acetic acid methyl ester; and

(R)-(3-{4-[5-Cyano-1-(2,4-dimethyl-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-phenoxy}-benzoylamino)-phenyl-acetic acid methyl ester,

or a pharmaceutically acceptable salt of any of the foregoing.

16. The compound of claim 13 wherein:

n is 0 or 1;

m is 1;

R 2 is cyano;

R 3 is trifluoromethyl;

R 4 is methyl, 1-methylethyl or chloro;

each R 5 is independently selected from the group consisting of phthalimidyl, —R 7 —C(S)N(R 8 ) 2 and —R 7 —S(O) t R 8 (where t is 0 or 2);

each R 7 is a direct bond; and

each R 8 is independently selected from hydrogen or alkyl.

17. The compound of claim 16 selected from the group consisting of the following:

1-(2,4-Dimethyl-benzyl)-6-[4-(4-methylsulfanyl-phenoxy)-phenyl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile;

1-(2,4-Dimethyl-benzyl)-6-{4-[4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-phenoxy]-phenyl}-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile;

3-{4-[5-Cyano-1-(2,4-dimethyl-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-phenoxy}-N,N-dimethyl-thiobenzamide; and

6-[3-Chloro-4-(4-methanesulfonyl-phenoxy)-phenyl]-1-(2,4-difluoro-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile,

or a pharmaceutically acceptable salt of any of the foregoing.

18. The compound of claim 3 wherein R 1 is heteroarylalkyl.

19. The compound of claim 18 wherein:

n is 0 or 1;

m is 0-2;

R 1 is optionally substituted thiazol-5-ylmethyl;

R 2 is cyano;

R 3 is trifluoromethyl;

R 4 is methyl, 1-methylethyl or chloro;

each R 5 is independently selected from the group consisting of halo, alkyl, alkenyl or haloalkyl.

20. The compound of claim 19 , i.e., namely 1-(2,5-Diethyl-thiazol-4-ylmethyl)-2-oxo-6-(4-phenoxy-phenyl)-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile, or a pharmaceutically acceptable salt thereof.

21. The compound of claim 2 wherein:

R 1 is aralkyl optionally substituted with one or more substituents independently selected from alkyl, halo or haloalkyl;

each R 5 is independently selected from the group consisting of halo, nitro, alkyl, alkenyl, haloalkyl, —R 7 —CN, —R 7 —N(R 8 ) 2 , —R 7 —OR 8 , —R 7 —C(O)R 11 , —R 7 —C(O)OR 8 , —R 7 —C(O)N(R 8 ) 2 , —R 7 —N(R 8 )C(O)OR 10 , —R 7 —S(O) t R 8 (where t is 0 to 2) and —R 7 —S(O) 2 N(R 8 ) 2 ;

R 6 is a direct bond, a straight or branched alkenylene chain or a straight or branched alkynylene chain;

each R 7 is independently selected from a direct bond or a straight or branched alkylene chain;

each R 8 is independently selected from hydrogen, alkyl, cycloalkyl, cycloalkylalkyl or heterocyclyl;

each R 9 is a straight or branched alkylene chain optionally substituted by aryl or heteroaryl;

R 10 is alkyl, aryl, aralkyl or cycloalkylalkyl; and

R 11 is hydrogen, alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, heteroaryl or heterarylalkyl.

22. The compound of claim 21 wherein:

n is 0;

m is 1 or 2;

R 1 is benzyl optionally substituted with one or more substituents independently selected from alkyl, halo or haloalkyl;

R 2 is cyano;

R 3 is trifluoromethyl;

each R 5 is independently selected from the group consisting of alkyl, trifluoromethyl, —R 7 —OR 8 and R 7 —S(O) t R 8 (where t is 0 to 2);

R 6 is a direct bond;

R 7 is a direct bond;

R 8 is hydrogen or alkyl; and

R 9 is a straight or branched alkylene chain.

23. The compound of claim 22 selected from the group consisting of the following:

1-(2,4-Difluoro-benzyl)-6-(4′-methanesulfonyl-biphenyl-3-yl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile;

1-(2,4-Difluoro-benzyl)-6-(4′-methanesulfonyl-biphenyl-4-yl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile;

1-(2,4-Difluoro-benzyl)-6-(4′-ethylsulfanyl-3′-trifluoromethyl-biphenyl-3-yl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile;

1-(2,4-Difluoro-benzyl)-6-(4′-ethanesulfonyl-3′-trifluoromethyl-biphenyl-3-yl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile;

1-(2,4-Difluoro-benzyl)-6-(4′-methylsulfanyl-3′-trifluoromethyl-biphenyl-3-yl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile;

1-(2,4-Difluoro-benzyl)-6-(5′-methylsulfanyl-3′-trifluoromethyl-biphenyl-3-yl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile;

1-(2,4-Difluoro-benzyl)-6-(4′-methylsulfanyl-3′-trifluoromethyl-biphenyl-4-yl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile;

1-(2,4-Difluoro-benzyl)-6-(5′-methylsulfanyl-3′-trifluoromethyl-biphenyl-4-yl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile;

1-(2,4-Difluoro-benzyl)-6-(4′-methanesulfonyl-3′-trifluoromethyl-biphenyl-3-yl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile;

1-(2,4-Difluoro-benzyl)-6-(4′-methanesulfonyl-3′-trifluoromethyl-biphenyl-4-yl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile;

1-(2,4-Difluoro-benzyl)-6-(3′-methanesulfonyl-5′-trifluoromethyl-biphenyl-4-yl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile;

1-(2,4-Difluoro-benzyl)-6-(3′-ethanesulfonyl-5′-trifluoromethyl-biphenyl-3-yl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile;

1-(2,4-Difluoro-benzyl)-2-oxo-6-[3′-(propane-2-sulfonyl)-5′-trifluoromethyl-biphenyl-3-yl]-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile;

1-(2,4-Difluoro-benzyl)-6-(4′-ethoxy-3′-methanesulfonyl-biphenyl-3-yl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile;

1-(2,4-Difluoro-benzyl)-2-oxo-6-[5′-(propane-1-sulfinyl)-3′-trifluoromethyl-biphenyl-3-yl]-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile;

6-[5′-(Butane-1-sulfinyl)-3′-trifluoromethyl-biphenyl-3-yl]-1-(2,4-difluoro-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile;

1-(2,4-Difluoro-benzyl)-2-oxo-6-(5′-phenylmethanesulfinyl-3′-trifluoromethyl-biphenyl-3-yl)-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile;

6-(5′-Cyclopropylmethanesulfinyl-3′-trifluoromethyl-biphenyl-3-yl)-1-(2,4-difluoro-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile;

1-(2,4-Difluoro-benzyl)-2-oxo-6-[5′-(propane-1-sulfinyl)-3′-trifluoromethyl-biphenyl-4-yl]-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile;

6-[5′-(Butane-1-sulfinyl)-3′-trifluoromethyl-biphenyl-4-yl]-1-(2,4-difluoro-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile;

1-(2,4-Difluoro-benzyl)-2-oxo-6-(5′-phenylmethanesulfinyl-3′-trifluoromethyl-biphenyl-4-yl)-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile;

6-(5′-Cyclopropylmethanesulfinyl-3′-trifluoromethyl-biphenyl-4-yl)-1-(2,4-difluoro-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile;

1-(2,4-Difluoro-benzyl)-6-(5′-ethanesulfinyl-3′-trifluoromethyl-biphenyl-4-yl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile;

1-(2,4-Difluoro-benzyl)-2-oxo-6-[3′-(propane-2-sulfinyl)-5′-trifluoromethyl-biphenyl-4-yl]-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile;

1-(2,4-Difluoro-benzyl)-2-oxo-6-[3′-(propane-1-sulfonyl)-5′-trifluoromethyl-biphenyl-3-yl]-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile;

1-(2,4-Difluoro-benzyl)-2-oxo-6-[3′-(propane-1-sulfonyl)-5′-trifluoromethyl-biphenyl-4-yl]-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile;

6-[3′-(Butane-1-sulfonyl)-5′-trifluoromethyl-biphenyl-3-yl]-1-(2,4-difluoro-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile;

6-[3′-(Butane-1-sulfonyl)-5′-trifluoromethyl-biphenyl-4-yl]-1-(2,4-difluoro-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile;

1-(2,4-Difluoro-benzyl)-2-oxo-6-(3′-phenylmethanesulfonyl-5′-trifluoromethyl-biphenyl-3-yl)-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile;

1-(2,4-Difluoro-benzyl)-2-oxo-6-(3′-phenylmethanesulfonyl-5′-trifluoromethyl-biphenyl-4-yl)-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile;

6-(3′-Cyclopropylmethanesulfonyl-5′-trifluoromethyl-biphenyl-3-yl)-1-(2,4-difluoro-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile;

6-(3′-Cyclopropylmethanesulfonyl-5′-trifluoromethyl-biphenyl-4-yl)-1-(2,4-difluoro-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile;

1-(2,4-Difluoro-benzyl)-6-(3′-ethanesulfonyl-5′-trifluoromethyl-biphenyl-4-yl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile;

1-(2,4-Difluoro-benzyl)-2-oxo-6-[3′-(propane-2-sulfonyl)-5′-trifluoromethyl-biphenyl-4-yl]-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile;

1-(2,4-Difluoro-benzyl)-6-(5′-isopropyl-3′-methanesulfonyl-biphenyl-3-yl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile;

1-(2,4-Difluoro-benzyl)-6-(5′-ethyl-3′-methanesulfonyl-biphenyl-3-yl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile;

1-(2,4-Difluoro-benzyl)-6-(3′-ethanesulfonyl-5′-isopropyl-biphenyl-3-yl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; and

1-(2,4-Difluoro-benzyl)-6-(3′-methanesulfonyl-5′-trifluoromethyl-biphenyl-3-yl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile,

or a pharmaceutically acceptable salt of any of the foregoing.

24. The compound of claim 21 wherein:

n is 0;

m is 1 or 2;

R 1 is benzyl optionally substituted with one or more substituents independently selected from alkyl, halo or haloalkyl;

R 2 is cyano;

R 3 is trifluoromethyl;

each R 5 is independently selected from the group consisting of alkyl, —R 7 —C(O)R 11 , —R 7 —C(O)OR 8 or —R 7 —C(O)N(R 8 ) 2 ;

R 6 is a direct bond;

each R 7 is a direct bond;

each R 8 is independently hydrogen, alkyl, aryl or aralkyl; and

R 11 is hydrogen, alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, pyrrolidinyl or piperidinyl.

25. The compound of claim 24 selected from the group consisting of the following:

6-(3′-Acetyl-biphenyl-3-yl)-1-(2,4-difluoro-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile;

6-(4′-Acetyl-biphenyl-3-yl)-1-(2,4-difluoro-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile;

3′-[5-Cyano-1-(2,4-difluoro-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-biphenyl-3-carboxylic acid amide;

3′-[5-Cyano-1-(2,4-difluoro-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-biphenyl-4-carboxylic acid amide;

3′-[5-Cyano-1-(2,4-difluoro-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-biphenyl-3-carboxylic acid dimethylamide;

3′-[5-Cyano-1-(2,4-difluoro-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-biphenyl-4-carboxylic acid dimethylamide;

1-(2,4-Difluoro-benzyl)-2-oxo-6-[3′-(pyrrolidine-1-carbonyl)-biphenyl-3-yl]-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile;

1-(2,4-Difluoro-benzyl)-2-oxo-6-[4′-(piperidine-1-carbonyl)-biphenyl-3-yl]-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile;

3′-[5-Cyano-1-(2,4-difluoro-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-biphenyl-3-carboxylic acid ethylamide;

3′-[5-Cyano-1-(2,4-difluoro-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-biphenyl-4-carboxylic acid methylamide;

3′-[5-Cyano-1-(2,4-difluoro-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-biphenyl-4-carboxylic acid phenylamide;

3′-[5-Cyano-1-(2,4-difluoro-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-biphenyl-4-carboxylic acid benzylamide;

{3′-[5-Cyano-1-(2,4-difluoro-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-biphenyl-3-yl}-acetic acid;

{4′-[5-Cyano-1-(2,4-difluoro-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-biphenyl-3-yl}-acetic acid;

{3′-[5-Cyano-1-(2,4-difluoro-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-biphenyl-4-yl}-acetic acid;

{4′-[5-Cyano-1-(2,4-difluoro-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-biphenyl-4-yl}-acetic acid;

{3-Chloro-3′-[5-cyano-1-(2,4-difluoro-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-biphenyl-4-yl}-acetic acid methyl ester; and

{3-Chloro-3′-[5-cyano-1-(2,4-difluoro-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-biphenyl-4-yl}-acetic acid,

or a pharmaceutically acceptable salt of any of the foregoing.

26. The compound of claim 21 wherein:

n is 0;

m is 0-2;

R 2 is cyano;

R 3 is trifluoromethyl;

each R 5 is independently selected from the group consisting of halo, alkyl, alkenyl, haloalkyl or —R 7 —OR 8 ;

R 6 is a direct bond, a straight or branched alkenylene chain or a straight or branched alkynylene chain;

R 7 is a direct bond; and

R 8 is hydrogen or alkyl.

27. The compound of claim 26 selected from the group consisting of the following:

6-(3′,5′-Bis-trifluoromethyl-biphenyl-3-yl)-1-(2,4-difluoro-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile;

6-(3′,5′-Bis-trifluoromethyl-biphenyl-4-yl)-1-(2,4-difluoro-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile;

6-(3′-Chloro-4′-ethoxy-biphenyl-3-yl)-1-(2,4-difluoro-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile;

1-(2,4-Difluoro-benzyl)-6-(3′,4′-dimethoxy-biphenyl-4-yl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile;

6-(3′-Chloro-4′-ethoxy-biphenyl-4-yl)-1-(2,4-difluoro-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile;

1-(2,4-Difluoro-benzyl)-2-oxo-6-(3-phenylethynyl-phenyl)-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile;

1-(2,4-Difluoro-benzyl)-2-oxo-6-(4-phenylethynyl-phenyl)-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile;

1-(2,4-Difluoro-benzyl)-2-oxo-6-[3-((E)-styryl)-phenyl]-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; and

1-(2,4-Difluoro-benzyl)-2-oxo-6-[4-((E)-styryl)-phenyl]-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile,

or a pharmaceutically acceptable salt of any of the foregoing.

28. The compound of claim 21 wherein:

n is 0;

m is 1 or 2;

R 2 is cyano;

R 3 is trifluoromethyl;

each R 5 is independently selected from the group consisting of nitro, —R 7 —N(R 8 ) 2 , —R 7 —OR 8 or —R 7 —N(R 8 )C(O)OR 10 ;

R 6 is a direct bond;

each R 7 is a direct bond;

each R 8 is independently selected from hydrogen or alkyl; and

R 10 is alkyl.

29. The compound of claim 28 selected from the group consisting of the following:

6-(3′-Amino-biphenyl-3-yl)-1-(2,4-difluoro-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile;

1-(2,4-Difluoro-benzyl)-6-(4′-ethoxy-3′-nitro-biphenyl-3-yl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile;

6-(3′-Amino-4′-ethoxy-biphenyl-3-yl)-1-(2,4-difluoro-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; and

{3′-[5-Cyano-1-(2,4-difluoro-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-4-ethoxy-biphenyl-3-yl}-carbamic acid tert-butyl ester,

or a pharmaceutically acceptable salt of any of the foregoing.

30. A method of reducing cholesterol levels in a subject in need thereof, comprising administering an effective amount of a compound of claim 1 , or a pharmaceutically acceptable salt thereof.

31. A method of increasing cholesterol efflux from cells of a subject, comprising administering an effective amount of a compound of claim 1 , or a pharmaceutically acceptable salt thereof.

32. A method of increasing the expression of ATP-Binding Cassette (ABC1) in the cells of a subject, comprising administering an effective amount of a compound of claim 1 , or a pharmaceutically acceptable salt thereof.

33. A method of reducing cholesterol levels in a subject in need thereof, comprising administering an effective amount of a compound of claim 1 .

34. A pharmaceutical composition comprising a pharmaceutically acceptable excipient and a compound of claim 1 .