IP Library › Patent Application 12341154
Patent Application
App. No. 12/341,154

Methods and Compositions for Use in Treating Cancer

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Quick Facts
Patent No.
US None
App. No.
12/341,154
Abstract

The invention provides methods and compositions for use in treating diseases associated with excessive cellular proliferation, such as cancer.

Claims (35)

1 . A method of treating cancer in a patient, said method comprising administering to said patient a compound having the formula:

or a pharmaceutically acceptable salt thereof, in combination with a second approach to treatment.

2 . The method of claim 1 , wherein said second approach to treatment comprises administration of a chemotherapeutic drug to said patient.

3 . The method of claim 2 , wherein said chemotherapeutic drug is selected from the group consisting of antimetabolites, antibiotics, alkylating agents, plant alkaloids, and hormonal agents.

4 . The method of claim 3 , wherein said chemotherapeutic drug is an antimetabolite.

5 . The method of claim 4 , wherein said antimetabolite is gemcitabine.

6 . The method of claim 5 , wherein said cancer is non-small cell lung carcinoma, pancreatic cancer, or metastatic breast cancer.

7 . The method of claim 4 , wherein said antimetabolite is capecitabine.

8 . The method of claim 7 , wherein said cancer is breast cancer or colorectal cancer.

9 . The method of claim 3 , wherein said antibiotic is an anthracycline.

10 . The method of claim 9 , wherein said anthracycline is doxorubicin.

11 . The method of claim 10 , wherein said cancer is breast cancer.

12 . The method of claim 3 , wherein said chemotherapeutic drug is an alkylating agent.

13 . The method of claim 12 , wherein said alkylating agent is carboplatinum or cisplatinum.

14 . The method of claim 13 , wherein said cancer is non-small cell lung cancer or ovarian cancer.

15 . The method of claim 3 , wherein said chemotherapeutic drug is a plant alkaloid.

16 . The method of claim 15 , wherein said plant alkaloid is irinotecan.

17 . The method of claim 16 , wherein said cancer is colorectal cancer.

18 . The method of claim 15 , wherein said plant alkaloid is topotecan.

19 . The method of claim 18 , wherein said cancer is ovarian cancer or non-small cell lung cancer.

20 . The method of claim 1 , wherein said second approach to treatment comprises administration of an anticoagulant to said patient.

21 . The method of claim 20 , wherein said anticoagulant is heparin.

22 . A composition comprising a compound having the formula:

or a pharmaceutically acceptable salt thereof, in combination with a second chemotherapeutic drug.

23 . The composition of claim 22 , wherein said chemotherapeutic drug is selected from the group consisting of antimetabolites, antibiotics, alkylating agents, plant alkaloids, and hormonal agents.

24 . The composition of claim 23 , wherein said chemotherapeutic drug is an antimetabolite.

25 . The composition of claim 24 , wherein said antimetabolite is gemcitabine.

26 . The composition of claim 24 , wherein said antimetabolite is capecitabine.

27 . The composition of claim 23 , wherein said antibiotic is an anthracycline.

28 . The composition of claim 27 , wherein said anthracycline is doxorubicin.

29 . The composition of claim 23 , wherein said chemotherapeutic drug is an alkylating agent.

30 . The composition of claim 29 , wherein said alkylating agent is carboplatinum or cisplatinum.

31 . The composition of claim 23 , wherein said chemotherapeutic drug is a plant alkaloid.

32 . The composition of claim 31 , wherein said plant alkaloid is irinotecan.

33 . The composition of claim 31 , wherein said plant alkaloid is topotecan.