Mixing bag with integral sparger and sensor receiver
A mixing bag for use in bioprocessing receives a fluid and includes a sensing element for measuring at least one property thereof. The bag may include an internal fluid-agitating element and an integral sparger. Related methods are also disclosed.
1. An apparatus for receiving a fluid and sensing a characteristic thereof using a sensor element in contact with the fluid, said sensor element adapted for being illuminated by light from a source, comprising:
a vessel having a flexible sidewall at least partially defining an interior compartment for receiving the fluid and for associating with the sensor element, a portion of the vessel formed by the flexible sidewall having no predetermined shape and capable of assuming a particular shape based on the presence of the fluid in the interior compartment; and
a receiver secured to the vessel adjacent to the sensor element, said receiver adapted for receiving and delivering light from the source to the sensor element.
2. The apparatus of claim 1 , wherein the receiver comprises a first portion adapted for being secured to the flexible sidewall and a second portion for contacting the sensor element.
3. The apparatus of claim 2 , wherein the second portion of the receiver includes a window adapted for transmitting light to the sensor element.
4. The apparatus of claim 3 , wherein the window includes an inner surface for contacting the sensor element.
5. The apparatus of claim 1 , wherein the receiver includes a cavity adapted for at least partially receiving the source of light for illuminating the sensor element.
6. The apparatus of claim 5 , wherein the receiver includes a window bounding the cavity for allowing the light from the source to reach the sensor element.
7. An apparatus intended for receiving a fluid and sensing a characteristic of the fluid, comprising:
a vessel having a flexible sidewall at least partially defining an interior compartment for receiving the fluid, a portion of the vessel formed by the flexible sidewall having no predetermined shape and capable of assuming a particular shape based on the presence of the fluid in the interior compartment; and
a sensor assembly carried by the vessel, the sensor assembly including an at least translucent portion in optical communication with a sensor element for contacting the fluid when the fluid is present in the interior compartment of the vessel.
8. The apparatus of claim 7 , wherein the at least translucent portion of the sensor assembly comprises a closed end of a tube.
9. The apparatus of claim 8 , wherein the tube is adapted for insertion into an opening of a receiver secured to the vessel.
10. The apparatus of claim 9 , wherein the receiver is welded to the flexible sidewall of the vessel to form a fluid-impervious seal.
11. The apparatus of claim 7 , wherein the sensor assembly further includes a cable for transmitting light to the sensor element.
12. The apparatus of claim 11 , wherein the sensor assembly further includes a receiver for receiving the cable for transmitting light to the sensor element.
13. The apparatus of claim 7 , wherein the at least translucent portion of the sensor assembly is transparent.
14. An apparatus intended for receiving a fluid and sensing a characteristic of the fluid, comprising:
a vessel having a flexible sidewall at least partially defining an interior compartment for receiving the fluid, said vessel including an opening, a portion of the vessel formed by the flexible sidewall having no predetermined shape and capable of assuming a particular shape based on the presence of the fluid in the interior compartment;
a sensor element for contacting the fluid when the fluid is present in the interior compartment of the vessel; and
a window secured adjacent the opening of the vessel, said window adapted for communicating with the sensor element.
15. The apparatus of claim 14 , further comprising a receiver carried by the vessel for receiving the window.
16. The apparatus of claim 15 , wherein the receiver is positioned in the opening of the vessel.
17. The apparatus of claim 15 , wherein the receiver is more rigid than the flexible sidewall of the vessel.
18. The apparatus of claim 14 , wherein the sensor element is positioned within the interior compartment of the vessel.
19. An apparatus for receiving a fluid and a sensor element in contact with the fluid, said sensor element adapted for being illuminated by light from a source, comprising:
a vessel having a flexible sidewall at least partially defining an interior compartment for receiving the fluid, said flexible sidewall providing the vessel with a portion having no predetermined shape and capable of assuming a particular shape based on the presence of the fluid in the interior compartment; and
an optical port carried by the vessel, said optical port comprising a window adapted for transmitting light from the source to the sensor element.
20. The apparatus of claim 19 , wherein the optical port comprises a cavity forming a passage providing a reference location external to the interior compartment for delivering the light to the sensor element via the window.
21. The apparatus of claim 19 , wherein the window includes a rigid portion connected to the sidewall and adapted for supporting the sensor element.
22. The apparatus of claim 1 , wherein the vessel comprises a bag including the flexible sidewall, and said receiver is connected to the flexible sidewall.
23. The apparatus of claim 1 , wherein the vessel comprises a bag having a rigid portion connected to the flexible sidewall.
24. An apparatus for receiving a fluid and sensing a characteristic of the fluid comprising:
a bag at least partially forming an interior compartment for receiving the fluid;
a sensor element for contacting the fluid when the fluid is in the interior compartment;
a receiver connected to the bag adjacent to the sensor element, said receiver adapted for receiving and delivering light to the sensor element;
a sparger connected to the bag for forming bubbles in the fluid; and
an agitator for agitating the fluid and assisting in distributing the bubbles throughout the fluid when present in the interior compartment.
25. The apparatus according to claim 24 , wherein the bag further comprises a rigid receiver for receiving the agitator.
26. The apparatus according to claim 24 , wherein the receiver comprises a window for transmitting light to the sensor element.