Liquid antiseptic compositions containing iodine and a sugar and/or sugar alcohol
View Patent ↗The present invention relates to compositions that contain iodine intended primarily for tissue antisepsis, particularly skin antisepsis.
1. A tissue antiseptic composition comprising:
an antimicrobial agent selected from the group consisting of iodine (I 2 ), an iodophor, and a combination thereof, wherein the antimicrobial agent is present in a sufficient concentration to provide an available iodine concentration of 0.1 wt-% to 2 wt-%;
a sugar alcohol of a monosaccharide;
a vehicle that is a liquid at 23° C. wherein the vehicle is water;
a surfactant selected from the group consisting of an anionic surfactant, a zwitterionic surfactant, and a combination thereof; and
a thickener;
wherein the composition is a liquid at 23° C., has a pH of 2 to 6, and has a viscosity of no greater than 100,000 cps at 23° C.
2. The tissue antiseptic composition of claim 1 further comprising an alpha-hydroxyacid.
3. The tissue antiseptic composition of claim 2 wherein the alpha-hydroxyacid is present in an amount greater than 1 wt-%.
4. The tissue antiseptic composition of claim 3 wherein the alpha-hydroxyacid is present in an amount greater than 2.5 wt-%.
5. The tissue antiseptic of claim 1 wherein the zwitterionic surfactant comprises a sultaine, betaine, phospholipid, or a combination thereof.
6. The tissue antiseptic of claim 1 wherein the anionic surfactant comprises a phosphate, phosphonate, sulfate, sulfonate, or a combination thereof.
7. The tissue antiseptic composition of claim 1 wherein the composition further comprises a nonionic surfactant.
8. The tissue antiseptic composition of claim 1 wherein the vehicle further comprises a glycol.
9. The tissue antiseptic composition of claim 8 wherein the vehicle further comprises a polyethylene glycol having a molecular weight of less than 1500.
10. The tissue antiseptic composition of claim 1 which is free of an antimicrobial lipid.
11. The tissue antiseptic composition of claim 1 having a viscosity of less than 1000 cps.
12. The tissue antiseptic composition of claim 1 having a viscosity of greater than 10 cps.
13. The tissue antiseptic composition of claim 1 which reduces normal skin flora by at least 1 log in 2 minutes on dry human skin site using ASTM testing method E1173-93 and a 30-second scrub with gauze soaked in the composition using moderate pressure.
14. The tissue antiseptic composition of claim 1 which is stable at 50° C. for greater than 7 days with no visible changes.
15. The tissue antiseptic composition of claim 1 wherein the composition has a pH of 3 to 5.
16. The tissue antiseptic composition of claim 1 wherein the sugar alcohol is present in an amount of at least 1 wt-%, based on the total weight of the composition.
17. The tissue antiseptic composition of claim 16 wherein the sugar alcohol is present in an amount of at least 4 wt-%, based on the total weight of the composition.
18. The tissue antiseptic composition of claim 1 wherein the sugar alcohol is completely soluble with no solid dispersed therein.
19. The tissue antiseptic composition of claim 1 wherein the sugar alcohol is selected from xylitol, mannitol, and combinations thereof.
20. The tissue antiseptic composition of claim 1 having a viscosity of no greater than 50,000 cps at 23° C.
21. The composition of claim 1 , wherein the sugar alcohol of a monosaccharide is present at a concentration of at least 0.25%.
22. A method of decolonizing the nasal passages of a subject, the method comprising applying the composition of claim 1 to the nasal passages of the subject.
23. A method of disinfecting the tissue of a subject, the method comprising applying the composition of claim 1 to the tissue of the subject.
24. A tissue antiseptic composition comprising:
an antimicrobial agent selected from the group consisting of iodine (I 2 ), an iodophor, and a combination thereof, wherein the antimicrobial agent is present in a sufficient concentration to provide an available iodine concentration of 0.1 wt-% to 2 wt-%;
a sugar alcohol of a monosaccharide;
a surfactant selected from the group consisting of an anionic surfactant, a zwitterionic surfactant, and a combination thereof;
a vehicle comprising water and a major amount of a water-soluble glycol humectant; and
a thickener;
wherein the composition is a liquid at 23° C., and has a pH of 2 to 6.
25. The tissue antiseptic composition of claim 24 wherein the composition further comprises a nonionic surfactant.
26. The tissue antiseptic composition of claim 24 wherein the glycol humectant is a polyethylene glycol having a molecular weight of less than 1500.
27. The tissue antiseptic composition of claim 24 further comprising an alpha-hydroxyacid.
28. The tissue antiseptic composition of claim 24 which is free of an antimicrobial lipid.
29. The tissue antiseptic composition of claim 24 wherein the composition has a pH of 3 to 5.
30. The tissue antiseptic composition of claim 24 wherein the sugar alcohol is present in an amount of at least 1 wt-%, based on the total weight of the composition.
31. The tissue antiseptic composition of claim 30 wherein the sugar alcohol is present in an amount of at least 4 wt-%, based on the total weight of the composition.
32. A method of decolonizing the nasal passages of a subject, the method comprising applying the composition of claim 24 to the nasal passages of the subject.
33. A method of disinfecting the tissue of a subject, the method comprising applying the composition of claim 24 to the tissue of the subject.
34. A tissue antiseptic composition comprising:
an antimicrobial agent selected from the group consisting of iodine (I 2 ), an iodophor, and a combination thereof, wherein the antimicrobial agent is present in a sufficient concentration to provide an available iodine concentration of 0.1 wt-% to 2 wt-%;
a sugar alcohol of a monosaccharide;
a vehicle wherein the vehicle is water;
a surfactant selected from the group consisting of an anionic surfactant, a zwitterionic surfactant, and a combination thereof; and
a hydroxycarboxylic acid;
wherein the composition has a viscosity of greater than 1000 cps and no greater than 100,000 cps at 23° C.; and
wherein the composition is a liquid at 23° C., and has a pH of 2 to 6.
35. The tissue antiseptic composition of claim 34 wherein the composition has a pH of 3 to 5.
36. The tissue antiseptic composition of claim 34 wherein the sugar alcohol is present in an amount of at least 1 wt-%, based on the total weight of the composition.
37. The tissue antiseptic composition of claim 36 wherein the sugar alcohol is present in an amount of at least 4 wt-%, based on the total weight of the composition.
38. A tissue antiseptic composition comprising:
an antimicrobial agent selected from the group consisting of iodine (I 2 ), an iodophor, and a combination thereof, wherein the antimicrobial agent is present in a sufficient concentration to provide an available iodine concentration of 0.1 wt-% to 2 wt-%;
xylitol;
a vehicle wherein the vehicle is water;
a surfactant selected from the group consisting of an anionic surfactant, a zwitterionic surfactant, and a combination thereof; and
a thickener;
wherein the composition is a liquid at 23° C., has a pH of 2 to 6, and has a viscosity of no greater than 100,000 cps at 23° C.
39. A tissue antiseptic composition comprising:
an antimicrobial agent selected from the group consisting of iodine (I 2 ), an iodophor, and a combination thereof, wherein the antimicrobial agent is present in a sufficient concentration to provide an available iodine concentration of 0.1 wt-% to 2 wt-%;
xylitol;
a vehicle wherein the vehicle is water;
a surfactant selected from the group consisting of an anionic surfactant, a zwitterionic surfactant, and a combination thereof; and
a hydroxycarboxylic acid;
wherein the composition has a viscosity of greater than 1000 cps and no greater than 100,000 cps at 23° C.; and
wherein the composition is a liquid at 23° C., and has a pH of 2 to 6.
40. A tissue antiseptic composition comprising:
an antimicrobial agent selected from the group consisting of iodine (I 2 ), an iodophor, and a combination thereof, wherein the antimicrobial agent is present in a sufficient concentration to provide an available iodine concentration of 0.1 wt-% to 2 wt-%;
a sugar alcohol of a monosaccharide;
a vehicle wherein the vehicle is water;
a surfactant selected from the group consisting of an anionic surfactant, a zwitterionic surfactant, and a combination thereof; wherein the anionic surfactant is selected from the group consisting of a phosphate, a phosphonate, a sulfate, a sulfonate, and a combination thereof; and
a thickener.
41. The tissue antiseptic of claim 40 wherein the surfactant is a zwitterionic surfactant.
42. The tissue antiseptic of claim 41 wherein the zwitterionic surfactant comprises a sultaine, betaine, phospholipid, or a combination thereof.
43. The tissue antiseptic of claim 40 wherein the surfactant is an anionic surfactant.
44. A method of decolonizing the nasal passages of a subject, the method comprising applying the composition of claim 40 to the nasal passages of the subject.
45. A method of disinfecting the tissue of a subject, the method comprising applying the composition of claim 40 to the tissue of the subject.
46. A tissue antiseptic composition comprising:
an antimicrobial agent selected from the group consisting of iodine (I 2 ), an iodophor, and a combination thereof, wherein the antimicrobial agent is present in a sufficient concentration to provide an available iodine concentration of 0.1 wt-% to 2 wt-%;
a sugar alcohol of a monosaccharide;
a vehicle wherein the vehicle is water;
a surfactant selected from the group consisting of a sultaine, a betaine, a phospholipid, a phosphate, a phosphonate, sulfate, a sulfonate, and a combination thereof; and
a thickener.