IP Library Patent Application 12350642
Patent Application
App. No. 12/350,642

COLORED OR COLORABLE TOPICAL COMPOSITION FOAM

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Patent No.
US None
App. No.
12/350,642
Abstract

There is described a colored or colorable topical composition, comprising: a) a foamable base composition comprising, 1) a flowable carrier composition; 2) a color agent; wherein the color agent is effective to impart, increase, decrease or otherwise affect color of a foam produced from the foamable composition and wherein the color agent is one or more agents selected from the group consisting of a colored active agent, a colored indicator, a colored excipient, a pigment, a dye, a colorant and a coloring agent; b) a propellant at a concentration of about 3% to about 25% by weight of the total composition; wherein the base composition has a first color; and wherein the foam comprising the colored or colorable topical composition has a second color upon dispensing from an aerosol container, and wherein the first color and the second color are visually different. There is also described a method of changing color, a method of administration, a use as a diagnostic and a kit.

Claims (137)

1 . A colored or colorable topical composition, comprising:

a. a foamable base composition comprising

i. a flowable carrier composition; and

ii. a color agent comprising a coal tar; and

b. a hydrocarbon propellant;

wherein the weight ratio of the foamable base composition to the hydrocarbon propellant ranges from about 100:3 to about 100:25;

wherein the base composition has a first color; and

wherein the foam of the colored or colorable topical composition has a second color upon dispensing from an aerosol container, and

wherein the color intensity of the first color is greater than the color intensity of the second color.

2 . The composition of claim 1 , wherein the second color is off-white.

3 . The composition of claim 1 , wherein the hydrocarbon propellant comprises at least one short chain hydrocarbon.

4 . The composition of claim 1 , wherein the hydrocarbon propellant comprises propane, butane, isobutane, or any mixtures thereof.

5 . The composition of claim 1 , wherein the foamable base composition comprises:

a) from about 3% to about 82% by weight hydrophobic carrier;

b) polymeric agent;

c) from about 2% to about 10% by weight surfactant;

d) from about 8% to about 98% by weight polar solvent;

e) from about 1% to about 5% by weight foam adjuvant;

wherein the hydrophobic carrier comprises isopropyl myristate, a silicone oil, an essential oil, a triglyceride, or any mixtures thereof.

6 . The composition of claim 1 , wherein the foamable base composition comprises:

a) from about 3% to about 82% by weight hydrophobic carrier;

b) from about 0.5% to about 3% by weight polymeric agent;

c) from about 2% to about 10% by weight surfactant;

d) from about 8% to about 98% by weight polar solvent;

e) from about 1% to about 5% by weight foam adjuvant;

wherein the hydrophobic carrier comprises isopropyl myristate, a silicone oil, an essential oil, a triglyceride, or any mixtures thereof.

7 . The composition of claim 1 , wherein the foamable base composition is an emulsion and comprises:

a) from about 11% to about 22% by weight hydrophobic carrier;

b) from about 0.5% to about 2.3% by weight polymeric agent;

c) from about 3.0% to about 5.5% by weight surfactant;

d) from about 8% to about 16% by weight polar solvent;

e) from about 1% to about 2% by weight foam adjuvant;

f) from about 50% to about 83% by weight water;

wherein the hydrophobic carrier comprises isopropyl myristate, a silicone oil, an essential oil, a triglyceride, or any mixtures thereof.

8 . The composition of claim 1 , wherein the foamable base composition is non-aqueous and comprises:

a) from about 3% to about 82% by weight hydrophobic carrier, wherein the hydrophobic carrier comprises a stearyl ether, a PPG alkyl ether, a mineral oil, a petrolatum, a silicone oil, a triglyceride, an ester of a fatty acid, an unsaturated oil, a polyunsaturated oil, an essential oil, or any mixtures thereof;

b) from about 1.8% to about 3% by weight polymeric agent;

c) from about 2% to about 10% by weight surfactant;

d) from about 85% to about 98% by weight polar solvent; and

e) from about 2% to about 5% by weight foam adjuvant.

9 . A colored or colorable topical composition, comprising:

a foamable base composition comprising a color agent comprising a coal tar, wherein the base composition is an oil in water emulsion and wherein the hydrophobic phase of the oil in water emulsion is present in the base composition at a concentration of at least about 5%; and

a hydrocarbon propellant

wherein the weight ratio of the foamable base composition to the hydrocarbon propellant ranges from about 100:3 to about 100:25;

wherein the base composition has a first color; and

wherein the foam of the colored or colorable topical composition has a second color upon dispensing from a pressurized container, and

wherein the color intensity of the first color is greater than the color intensity of the second color.

10 . The composition of claim 9 , wherein the second color is off-white

11 . The composition of claim 9 , wherein the coal tar is provided as a coal tar extract or tincture dissolved in all or part of the polar solvent.

12 . The composition of claim 9 wherein the hydrophobic phase of the oil in water emulsion is present in the base composition at a concentration of at least about 10%.

13 . The composition of claim 9 , wherein the hydrophobic phase of the oil in water emulsion comprises isopropyl myristate.

14 . The composition of claim 9 , wherein the hydrophobic phase of the oil in water emulsion comprises a silicone oil.

15 . The composition of claim 14 , wherein the silicone oil comprises dimethicone, cyclomethicone, polyalkyl siloxane, polyaryl siloxane, polyalkylaryl siloxane, polyether siloxane copolymer, poly(dimethylsiloxane)-(diphenyl-siloxane) copolymer, or any mixtures thereof.

16 . The composition of claim 9 , wherein the hydrophobic phase of the oil in water emulsion comprises a triglyceride.

17 . The composition of claim 9 , wherein the base composition comprises:

a) from about 11% to about 22% by weight hydrophobic carrier;

b) from about 0.5% to about 2.3% by weight polymeric agent;

c) from about 3.0% to about 5.5% by weight surfactant;

d) from about 8% to about 16% by weight polar solvent;

e) from about 1% to about 2% by weight foam adjuvant; and

f) from about 50% to about 83% by weight water.

18 . The composition of claim 17 , wherein the hydrophobic carrier comprises isopropyl myristate, a silicone oil, a triglyceride, an essential oil, octyl dodecanol, lanolin or any mixtures thereof.

19 . The composition of claim 17 , wherein the polar solvent comprises a short chain alcohol, glycerol, propylene glycol or any mixtures thereof.

20 . The composition of claim 19 , wherein the short chain alcohol comprises ethanol.

21 . The composition of claim 17 , wherein the surfactant comprises of ceteareth 20, glyceryl stearate, PEG 40 stearate, polysorbate 60, laureth-4, emulgin B2 or any mixtures thereof.

22 . The composition of claim 17 , wherein the foam adjuvant comprises a fatty alcohol having 15 or more carbons in the carbon chain, a fatty acid having 16 or more carbons in the carbon chain, or any mixtures thereof.

23 . The composition of claim 17 , wherein the polymeric agent comprises hypromellose, xanthan gum, methocel K100, carboxymethylcellulose or any mixtures thereof.

24 . The composition of claim 17 , wherein the hydrophobic carrier comprises at least two of isopropyl myristate, a triglyceride or silicone oil;

wherein the polymeric agent comprises hypromellose K100M or xanthan gum; and

wherein the polar solvent comprises a short chain alcohol and glycerin.

25 . The composition of claim 1 , further comprising as an additional component an anti-perspirant, an anti-static agent, a buffering agent, a bulking agent, a chelating agent, a colorant, a conditioner, a deodorant, a diluent, a dye, an emollient, fragrance, a humectant, an occlusive agent, a penetration enhancer, a perfuming agent, a permeation enhancer, a pH-adjusting agent, a preservative, a skin penetration enhancer, a sunscreen, a sun blocking agent, a sunless tanning agent, a vitamin, or any mixtures thereof.

26 . A method of treating, alleviating or preventing a disorder, comprising:

administering topically to a surface having the disorder, a foamed composition comprising:

a. a foamable base composition comprising

i. a flowable carrier composition; and

ii. a color agent comprising a coal tar; and

b. a hydrocarbon propellant;

wherein the weight ratio of the foamable base composition to the hydrocarbon propellant ranges from about 100:3 to about 100:25;

wherein the base composition has a first color; and

wherein the foam of the colored or colorable topical composition has a second color upon dispensing from an aerosol container, and

wherein the color intensity of the first color is greater than the color intensity of the second color.

27 . The method of claim 26 , wherein the second color is off-white.

28 . The method of claim 26 , wherein the hydrocarbon propellant comprises at least one short chain hydrocarbon.

29 . The claim of claim 26 , wherein the hydrocarbon propellant comprises propane, butane, isobutane, or any mixtures thereof.

30 . The method of claim 26 , wherein the foamable base composition comprises:

a) from about 3% to about 82% by weight hydrophobic carrier;

b) from about 0.5% to about 3% by weight polymeric agent;

c) from about 2% to about 10% by weight surfactant;

d) from about 8% to about 98% by weight polar solvent;

e) from about 1% to about 5% by weight foam adjuvant;

wherein the hydrophobic carrier comprises isopropyl myristate, a silicone oil, an essential oil, a triglyceride, or any mixture thereof.

31 . The method of claim 26 , wherein the foamable base composition is an emulsion and comprises:

a) from about 11% to about 22% by weight hydrophobic carrier;

b) from about 0.5% to about 2.3% by weight polymeric agent;

c) from about 3.0% to about 5.5% by weight surfactant;

d) from about 8% to about 16% by weight polar solvent;

e) from about 1% to about 2% by weight foam adjuvant;

f) from about 50% to about 83% by weight water;

wherein the hydrophobic carrier comprises isopropyl myristate, a silicone oil, an essential oil, a triglyceride, or any mixture thereof.

32 . The method of claim 26 , wherein the flowable carrier is non-aqueous and comprises:

a) from about 3% to about 82% by weight hydrophobic carrier, comprises a stearyl ether, a PPG alkyl ether, a mineral oil, a petrolatum, a silicone oil, a triglyceride, an ester of a fatty acid, an unsaturated oil, a polyunsaturated oil or an essential oil;

b) from about 1.8% to about 3% by weight polymeric agent;

c) from about 2% to about 10% by weight surfactant;

d) from about 85% to about 98% by weight polar solvent; and

e) from about 2% to about 5% by weight foam adjuvant.

33 . A method of treating, alleviating or preventing a disorder, comprising:

administering topically to a body surface having the disorder, a foamed composition comprising:

a foamable base composition comprising a color agent comprising a coal tar, wherein the base composition is an oil in water emulsion and wherein the hydrophobic phase of the oil in water emulsion is present in the base composition at a concentration of at least about 5%; and

a hydrocarbon propellant;

wherein the weight ratio of the foamable base composition to the hydrocarbon propellant ranges from about 100:3 to about 100:25;

wherein the base composition has a first color; and

wherein the foam of the foamed composition has a second color upon dispensing from a pressurized container, and

wherein the color intensity of the first color is greater than the color intensity of the second color.

34 . The method of claim 33 , wherein the second color is off-white.

35 . The method of claim 33 , wherein the coal tar is provided as a coal tar extract or tincture dissolved in all or part of the polar solvent.

36 . The method of claim 33 , wherein the hydrophobic phase of the oil in water emulsion is present in the base composition at a concentration of at least about 10%.

37 . The method of claim 33 , wherein the hydrophobic base of the oil in the water emulsion comprises isopropyl myristate.

38 . The method of claim 33 , wherein the hydrophobic phase of the oil in water emulsion comprises a silicone oil.

39 . The method of claim 38 , wherein the silicone oil comprises dimethicone, cyclomethicone, polyalkyl siloxane, polyaryl siloxane, polyalkylaryl siloxane, polyether siloxane copolymer, poly(dimethylsiloxane)-(diphenyl-siloxane) copolymer, or any mixtures thereof.

40 . The method of claim 33 , wherein the hydrophobic phase of the oil in water emulsion comprises a triglyceride.

41 . The method of claim 33 , wherein the base composition comprises:

a) from about 11% to about 22% by weight hydrophobic carrier;

b) from about 0.5% to about 2.3% by weight polymeric agent;

c) from about 3.0% to about 5.5% by weight surfactant;

d) from about 8% to about 16% by weight polar solvent;

e) from about 1% to about 2% by weight foam adjuvant; and

f) from about 50% to about 83% by weight water.

42 . The method of claim 41 , wherein the hydrophobic carrier comprises isopropyl myristate, a silicone oil, a triglyceride, an essential oil, octyl dodecanol, lanolin or any mixtures thereof.

43 . The method of claim 41 , wherein the polar solvent comprises short chain alcohol, glycerol, propylene glycol or any mixtures thereof.

44 . The method of claim 41 , wherein the short chain alcohol comprises ethanol.

45 . The method of claim 41 , wherein the surfactant comprises ceteareth 20, glyceryl stearate, PEG 40 stearate, polysorbate 60, laureth-4, emulgin B2 or any mixtures thereof.

46 . The method of claim 41 , wherein the foam adjuvant comprises a fatty alcohol having 15 or more carbons in the carbon chain, a fatty acid having 16 or more carbons in the carbon chain, or any mixtures thereof.

47 . The method of claim 41 , wherein the polymeric agent comprises hypromellose, xanthan gum, methocel K100, carboxymethylcellulose or any mixtures thereof.

48 . The method of claim 41 , wherein the hydrophobic carrier comprises at least two of isopropyl myristate, a triglyceride and silicone oil;

wherein the polymeric agent comprises hypromellose K100M or xanthan gum; and

wherein the polar solvent comprises a short chain alcohol and glycerin,

49 . The method of claim 26 wherein the disorder comprises a disorder associated with hyperkeratinization, dandruff, seborrheic dermatitis, or psoriasis.

Assignments (2)
CHANGE OF NAME Recorded Jul 30, 2014
From: FOAMIX LTD.
To: FOAMIX PHARMACEUTICALS LTD.
Reel/Frame 033445/0249 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 6, 2014
From: TAMARKIN, DOV; FRIEDMAN, DORON; EINI, MEIR
To: FOAMIX LTD.
Reel/Frame 032162/0361 →