9-substituted minocycline compounds
View Patent ↗The present invention pertains, at least in part, to novel 9-substituted minocycline compounds. These minocycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
1. A minocycline compound selected from the group consisting of:
and a pharmaceutically acceptable salt thereof.
2. A method for treating a bacterial infection in a mammal, comprising administering to said mammal a minocycline compound of claim 1 , such that said mammal is treated.
3. The method of claim 2 , wherein said bacterial infection is an E. coli infection.
4. The method of claim 2 , wherein said bacterial infection is a S. aureus infection.
5. The method of claim 2 , wherein said bacterial infection is an E. faecalis infection.
6. The method of claim 2 , wherein said bacterial infection is resistant to other tetracycline antibiotics.
7. The method of claim 2 , wherein said minocycline compound is administered with a pharmaceutically acceptable carrier.
8. The method of claim 2 , wherein said mammal is a human.
9. A pharmaceutical composition comprising a therapeutically effective amount of a minocycline compound of claim 1 and a pharmaceutically acceptable carrier.