Bioabsorbable Surgical Compositions
Compounds are provided which can form bioabsorbable compositions useful as adhesives or sealants for medical/surgical applications.
1 . A two component bioabsorbable composition comprising:
a first component including a polyamine, a hydrophilic solvent and a thickening agent; and,
a second component including an aliphatic polyester macromer.
2 . The two component bioabsorbable composition according to claim 1 , wherein the thickening agent comprises a polysaccharide.
3 . The two component bioabsorbable composition according to claim 1 , wherein the thickening agent is selected from the group consisting of polyacrylic acid, poly(sodium acrylate), poly(N-isopropylacrylamide), sodium alginate, guar gum, sodium carboxymethyl guar, cellulose, hydroxyethyl cellulose, carboxymethyl cellulose, konjac glucomannan, oat starch, potato starch, corn starch, xanthan gum, curdlan and combinations thereof.
4 . The two component bioabsorbable composition according to claim 3 , wherein the thickening agent comprises carboxymethyl cellulose.
5 . The two component bioabsorbable composition according to claim 1 , wherein the hydrophilic solvent is selected from the group consisting of water, saline, and pH buffer solutions.
6 . The two component bioabsorbable composition according to claim 1 , wherein the polyamine is selected from the group consisting of ethylene diamine, hexamethylene diamine, lysine, spermine, spermidine, N-(3-aminopropyl)-1,4-butanediamine, N,N′-bis(3-aminopropyl)-1,4-butanediamine, isomers of hexamethylene diamine, diethylene triamine, triethylene tetramine, tetraethylene pentamine, bis-hexamethylene triamine, N,N′-bis(3-aminopropyl)-1,2-ethane diamine, N-(3-Aminopropyl)-1,3-propane diamine, N-(2-aminoethyl)-1,3 propane diamine, cyclohexane diamine, isomers of cyclohexane diamine, 4,4′-methylene biscyclohexane amine, 4′4′-methylene bis(2-methylcyclohexanamine), toluene diamine, phenylene diamine, isophorone diamine, phenalkylene polyamines, amino-functionalized polyalkylene oxides, polypeptides and combinations thereof.
7 . The two component bioabsorbable composition according to claim 6 , wherein the polyamine comprises N-(3-Aminopropyl)-1,3-propane diamine.
8 . The two component bioabsorbable composition according to claim 6 , wherein the polyamine is at a concentration of from about 0.001% w/w to about 10% w/w.
9 . The two component bioabsorbable composition according to claim 1 , wherein the polyamine comprises an amino acid.
10 . The two component bioabsorbable composition according to claim 1 , wherein the aliphatic polyester macromer is a compound of the formula:
HO—(R-A) n -R—OH
wherein A is a group derived from an aliphatic diacid; R can be the same or different at each occurrence and is a group derived from a dihydroxy compound having a molecular weight less than 1,000; and n is 2 to 10.
11 . The two component bioabsorbable composition according to claim 1 , wherein the aliphatic polyester macromer is a compound of the formula:
OCN—X—HNCOO—(R-A) n -R OOCNH—X—NCO
wherein X is an aliphatic or aromatic group; A is a group derived from an aliphatic diacid; R can be the same or different at each occurrence and is a group derived from a dihydroxy compound; and n is 1 to 10.
12 . The two component bioabsorbable composition according to claim 1 , wherein the aliphatic polyester macromer is a compound of the formula:
Z—(OOCNH—X—NHCOO—(R-A) n R—OOCNH—X—NCO) m
wherein Z is a group derived from a multifunctional compound; X is an aliphatic or aromatic group; A is a group derived from an aliphatic diacid; R can be the same or different at each occurrence and is a group derived from a dihydroxy compound; n is 1 to 10; and m is 2 to 6.
13 . The two component bioabsorbable composition according to claim 1 wherein A is a group derived from adipic acid.
14 . The two component bioabsorbable composition according to claim 1 wherein R is a group derived from a polyalkylene glycol.
15 . The two component bioabsorbable composition according to claim 1 wherein R is a group derived from a polyethylene glycol.
16 . The two component bioabsorbable composition according to claim 1 wherein R is a group derived from a compound selected from the group consisting of PEG 400, PEG 600 and PEG 900.
17 . A method comprising applying the two component bioabsorbable composition of claim 1 to tissue.
18 . The two component bioabsorbable composition according to claim 1 , wherein the first component and the second component are reacted in situ creating a cross-linked polyurethane.
19 . A method of sealing a tissue defect comprising applying the two component bioabsorbable composition of claim 1 to a tissue defect.
20 . A method of adhering a surgical implant to tissue comprising contacting the surgical implant and tissue with a two component bioabsorbable composition of claim 1 .