Pro104 antibody compositions and methods of use
The invention provides isolated anti-ovarian, pancreatic, lung or breast cancer antigen (Pro104) antibodies that bind to Pro104 on a mammalian cell in vivo. The invention also encompasses compositions comprising an anti-Pro104 antibody and a carrier. These compositions can be provided in an article of manufacture or a kit. Another aspect of the invention is an isolated nucleic acid encoding an anti-Pro104 antibody, as well as an expression vector comprising the isolated nucleic acid. Also provided are cells that produce the anti-Pro104 antibodies. The invention encompasses a method of producing the anti-Pro104 antibodies. Other aspects of the invention are a method of killing a Pro104-expressing cancer cell, comprising contacting the cancer cell with an anti-Pro104 antibody and a method of alleviating or treating a Pro104-expressing cancer in a mammal, comprising administering a therapeutically effective amount of the anti-Pro104 antibody to the mammal.
1. An isolated Pro104 specific siRNA, wherein the Pro104 specific siRNA is selected from the group comprising SEQ ID NO:11-14, SEQ ID NO:19-33 or SEQ ID NO: 37-38.
2. The Pro104 specific siRNA of claim 1 which knocks-down Pro104 mRNA.
3. The Pro104 specific siRNA of claim 1 which down regulates Pro104 protein expression.
4. The Pro104 specific siRNA of claim 1 which induces apoptosis.
5. The Pro104 specific siRNA of claim 1 further comprising two thymidine residues (dTdT) at the 3′ end of the sequence.
6. An isolated Pro104 specific siRNA, wherein the Pro104 specific siRNA comprises a sequence selected from the group consisting of SEQ ID NO:11-14, SEQ ID NO:19-33 and SEQ ID NO: 37-38.
7. The Pro104 specific siRNA of claim 6 which knocks-down Pro104 mRNA.
8. The Pro104 specific siRNA of claim 6 which down regulates Pro104 protein expression.
9. The Pro104 specific siRNA of claim 6 which induces apoptosis.
10. The Pro104 specific siRNA of claim 6 further comprising two thymidine residues (dTdT) at the 3′ end of the sequence.
11. An isolated Pro104 specific siRNA consisting of SEQ ID NO:34.
12. An isolated Pro104 specific siRNA consisting of SEQ ID NO:34 with two thymidine residues (dTdT) at the 3′ end of the sequence.