Transdermal integrated actuator device, methods of making and using same
View Patent ↗The invention provides for a device for delivering a drug comprising: a. forming one or more micropores in a tissue membrane; and b. applying a patch containing a drug to the one or more micropores formed in the tissue membrane The invention also provides for methods of making and methods of using the same.
1. A device comprising:
(a) a poration device comprising
(i) an outer body defining a top of said poration device, said outer body containing a cavity;
(ii) a controller board comprising driving electronics and a battery, said controller board being positioned within said cavity; and
(iii) a tissue interface layer for contacting a tissue membrane of an animal, said tissue interface layer containing at least one probe element, each at least one probe element comprising a heated resistive element configured to conductively deliver thermal energy to cause ablation of said tissue membrane to a desired depth for formation of at least one micropore in said tissue membrane;
(b) a patch comprising a drug, said patch applied to a microporated area of said tissue membrane after poration; and
(c) an extension tab comprising a perforated tear line and releasably connected to a periphery of said tissue interface layer and a periphery of said patch.
2. The integrated poration and patch device according to claim 1 , wherein the patch is a permeable solid structure.
3. The integrated poration and patch device according to claim 2 , wherein the permeable solid structure is a porous polymer.
4. The integrated poration and patch device according to claim 1 , wherein said tissue interface layer comprises a material selected from the group of a woven material, a film, a supporting layer, and a sheet.
5. The integrated poration and patch device according to claim 1 , wherein said at least one probe element comprises a plurality of probe elements.
6. The integrated poration and patch device according to claim 4 , wherein the plurality of probe elements form an array.
7. The integrated poration and patch device according to claim 1 , wherein said tissue interface layer is removably attached to said outer body.
8. The integrated poration device and patch according to claim 1 , further comprising a control button for initiating poration of said tissue membrane.
9. The integrated poration device system according to claim 1 , wherein said tissue interface layer further comprises an adhesive layer for attachment of said poration device to said tissue membrane.
10. A system for selective formation of a plurality of micropores within a tissue membrane, comprising:
(a) an outer body defining a cavity;
(b) a controller board comprising driving electronics, said controller board being positioned within said cavity;
(c) a thin film configured for contacting the tissue membrane, the thin film comprising a plurality of probe elements configured for selective formation of the plurality of micropores, each probe element of the plurality of probe elements comprising a heated resistive element configured to conductively deliver thermal energy to cause ablation of the tissue membrane to a desired depth for formation of at least one micropore in the tissue membrane, said thin film being in select electrical communication with the controller board;
(d) a patch comprising a drug, said patch applied to the plurality of micropores in the tissue membrane after poration; and
(e) an extension tab comprising a perforated tear line and releasably connected to a periphery of said thin film and a periphery of said patch.
11. The poration and patch system according to claim 10 , wherein the patch is a permeable solid structure.
12. The poration and patch system according to claim 11 , wherein the permeable solid structure is a porous polymer.
13. The poration and patch system according to claim 10 , wherein the plurality of probe elements form an array.
14. The poration and patch system according to claim 10 , wherein the thin film is removably attached to said outer body.
15. The poration and patch system according to claim 10 , further comprising a control button for initiating poration of the tissue membrane.
16. The poration and patch system according to claim 10 , further comprising:
a tissue interface layer; and
an adhesive layer for selectively releasable attachment of the tissue interface layer to the tissue membrane, wherein the thin film is positioned within the tissue interface layer.