Pharmaceutical compositions comprising cyclosporins
View Patent ↗A composition is described herein comprising cyclosporin A, polysorbate 80, a polyoxyethylene stearate, and an oil; wherein the composition is an emulsion which is ophthalmically acceptable. Methods of treating diseases or conditions using said compositions, and medicaments related thereto, are also disclosed herein.
1. A composition comprising cyclosporine A in a concentration of 0.001% to 0.005% w/v, polysorbate 80, sodium carboxymethylcellulose, mannitol, glycerine and a preservative wherein the composition is a solution which is ophthalmically acceptable.
2. The composition of claim 1 wherein the preservative is an oxychloro compound.
3. The composition of claim 1 wherein polysorbate 80 is present in an amount of 1.0% w/v.
4. The composition of claim 1 wherein the sodium carboxymethylcellulose is present in an amount of 0.5% w/v.
5. The composition of claim 4 further comprising sodium citrate dehydrate.
6. The composition of claim 5 , wherein glycerine is present in the amount of 1.0% w/v.
7. The composition of claim 6 further comprising boric acid.
8. The composition of claim 6 further comprising Pemulen.
9. A composition consisting essentially of cyclosporine A in a concentration of 0.001% to 0.005% w/v, polysorbate 80, sodium carboxymethylcellulose, mannitol, glycerine and a preservative wherein the composition is a solution which is ophthalmically acceptable.