Nutritional composition with improved digestibility
The present invention is directed an improved nutritional composition, methods of improving digestion, and methods of enhancing the bioavailability of TGF-β.
1. An infant formula comprising:
a. a protein source comprising about 1.8 to about 2.5 g/100 Kcal;
b. a fat source comprising about 5.5 to about 5.7 g/100 Kcal;
c. a carbohydrate source comprising about 10.5 to about 11.0 g/100 Kcal;
d. a supplemental calcium source comprising calcium gluconate, calcium D-saccharate, calcium aspartate, calcium propionate, and combinations thereof;
e. DHA comprising about 15 to about 20 mg/100 Kcal;
f. ARA comprising about 23 to about 27 mg/100 Kcal;
g. a prebiotic comprising:
i. about 0.5 to about 0.7 mg/100 Kcal galacto-oligosaccharide; or
ii. about 0.2 to about 0.4 mg/100 Kcal polydextrose and about 0.2 to about 0.4 mg/100 Kcal galacto-oligosaccharide; and
h. TGF-β.
2. The infant formula of claim 1 wherein from about 40% to about 70% of protein source comprises whey protein.
3. The infant formula of claim 1 wherein from about 30% to about 60% of protein source comprises casein.
4. The infant formula of claim 1 wherein calcium gluconate is the sole supplemental calcium source.
5. The infant formula of claim 1 wherein the product is a composition selected from the group consisting of infant formula, children's nutritional product, pediatric nutritional formula, toddler nutritional formula, growing up milk, human milk supplement, and medical food.
6. The infant formula of claim 1 wherein the product is in a form selected from the group consisting of powder, liquid concentrate, ready-to-use, and acidified product.
7. The infant formula of claim 1 wherein the product is added to human milk prior to consumption.
8. The infant formula of claim 1 wherein the prebiotic comprises about 0.5 to about 0.7 mg/100 Kcal galacto-oligosaccharide.
9. The infant formula of claim 1 wherein the prebiotic comprises about 0.2 to about 0.4 mg/100 Kcal polydextrose and about 0.2 to about 0.4 mg/100 Kcal galacto-oligosaccharide.
10. The infant formula of claim 1 wherein the fat source comprises about 5.6 g/100 Kcal.
11. The infant formula of claim 1 wherein DHA comprises about 17 mg/100 Kcal.
12. The infant formula of claim 1 wherein ARA comprises about 25 mg/100 Kcal.
13. The infant formula of claim 1 wherein TGF-β is present in a level of from about 0.0150 (pg/μg) ppm to about 0.1000 (pg/μg) ppm.
14. The infant formula of claim 1 wherein TGF-β is present in a level of from about 0.0300 (pg/μg) ppm to about 0.0600 (pg/μg) ppm.
15. The infant formula of claim 1 wherein TGF-β is present in a level of from about 2500 pg/mL to about 10,000 pg/mL.
16. The infant formula of claim 1 wherein TGF-β is present in a level of from about 4000 pg/mL to about 6000 pg/mL.
17. The infant formula of claim 1 wherein the TGF-β has a bioactivity of from about 500 ng Eq/100 kcal to about 5000 ng Eq/100 kcal.
18. The infant formula of claim 1 wherein the TGF-β has a bioactivity of from about 800 ng Eq/100 kcal to about 2500 ng Eq/100 kcal.
19. The infant formula of claim 1 wherein the TGF-β comprises TGF-β1 and TGF-β2 and the ratio of TGF-β1:TGF-β2 is from about 1:5 to about 1:15.
20. The infant formula of claim 1 wherein the TGF-β comprises TGF-β1 and TGF-β2 and the ratio of TGF-β1:TGF-β2 is from about 1:8 to about 1:13.
21. The infant formula of claim 1 additionally comprising an added source of TGF-β.
22. The infant formula of claim 21 wherein the additional source of TGF-β comprises a whey protein concentrate.
23. The infant formula of claim 1 wherein the supplemental calcium source further comprises calcium lactate, calcium sulfate, calcium chloride, calcium citrate, calcium phosphate and combinations thereof.