Dip coated compositions containing a starch having a high amylose content
View Patent ↗The present invention features a method of making a coated tablet by dipping a core comprising an active agent into a coating liquid and drying said dipped core to form a outer-coating on the core, wherein the coating liquid contains at least one a starch having an amylose content of at least about 50 percent by weight of said starch.
1. A method of making a coated tablet, said method comprising dipping a core comprising an active agent into a coating liquid and drying said dipped core to form an outer-coating on said core, wherein said coating liquid comprises at least one starch having an amylose content of at least about 50 percent by weight of said starch, wherein said at least one starch is a pea starch, wherein said coating liquid additionally comprises at least one gum, wherein the weight ratio of said at least one starch to said at least one gum is from about 250:1 to about 100:1, and wherein said coating liquid comprises, based upon the total weight of the coating liquid, from about 10 percent to about 40 percent of said at least one starch.
2. A method of claim 1 , wherein said at least one gum is selected from the group consisting of xanthan gum, locust bean gum, tara gum, and mixtures thereof.
3. A method of claim 1 , wherein said coating liquid comprises both xanthan gum and locust bean gum.
4. A method of claim 1 , wherein said coating liquid additionally comprises at least one plasticizer.
5. A method of claim 4 , wherein said plasticizer is selected from the group consisting of glycerin, propylene glycol, polyethylene glycol, triethyl citrate and tributyl citrate.
6. A method of claim 1 , wherein said coating liquid comprises, based upon the total weight of the coating liquid,
a) from about 0.01 percent to about 0.5 percent of locust bean gum;
b) from about 0.01 percent to about 0.5 percent ofxanthan gum; and
c) from about 1 percent to about 10 percent of glycerin.
7. A method of claim 1 , wherein said core has a first end and a second end, and said method comprising dipping said first end of the core into said coating liquid and drying said dipped first end to form a outer-coating on said first end and said method further comprises dipping said second end in a second coating liquid and drying said dipped second end to form a second outer-coating on said second end, wherein said second coating liquid also comprises at least one said starch and wherein said second coating liquid is a different color from said first coating liquid.
8. A method of claim 1 , wherein said method further comprises creating one or more openings in said coating to expose said core on the surface of said coated tablet.
9. A method of claim 1 , wherein the viscosity of the coating liquid is from about 400 to about 3000 cps.
10. A method of claim 1 , wherein said liquid medium comprises water.
11. A method of claim 1 , wherein the percent solids of the coating liquid is from about 20 percent to about 45 percent.
12. A coated tablet manufactured by the method of claim 1 .
13. A coated tablet of claim 12 , wherein the resulting outer-coating comprises, based upon the total dried weight of the outer-coating, from about 75 percent to about 99 percent of said at least one starch.
14. A coated tablet of claim 12 , wherein said coating comprises, based upon the total dried weight of the coating,
a) from about 70 percent to about 99 percent of pea starch having an amylose content of at least about 50 percent by weight of said starch;
b) from about 0.05 percent to about 1 percent of locust bean gum;
b) from about 0.05 percent to about 1 percent of xanthan gum; and
c) from about 0.5 percent to about 15 percent of glycerin.
15. A method of claim 1 , wherein said core comprises a subcoating.
16. A method of claim 3 , wherein said core comprises a subcoating.
17. A method of claim 6 , wherein said core comprises a subcoating.