IP Library › Granted Patent US 7,960,408
Granted Patent B2
US 7,960,408 · App. 12/372,699 · Granted Jun 14, 2011

Quinolinyl and benzothiazolyl modulators

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Quick Facts
Patent No.
US 7,960,408
App. No.
12/372,699
Granted
Jun 14, 2011
Kind
B2
Abstract

Compounds, compositions and methods are provided that are useful in the treatment or prevention of a condition or disorder mediated by PPARγ. In particular, the compounds of the invention modulate the function of PPARγ. The subject methods are particularly useful in the treatment and/or prevention of diabetes, obesity, hypercholesterolemia, rheumatoid arthritis and atherosclerosis.

Claims (25)

1. A method for treating a metabolic disorder comprising administering to a subject having the metabolic disorder a therapeutically effective amount of a compound having the formula:

wherein

A is Cl or CF 3 ;

C is Cl or CF 3 ;

D is H or CH 3 ;

V is F or Cl;

Xis a member selected from the group consisting of H, CH 3 , COOH, and CO 2 CH 3 ; and

Y is a member selected from the group consisting of H, CO 2 H and CO 2 CH 3 ;

or a pharmaceutically acceptable salt thereof;

wherein the metabolic disorder is selected from the group consisting of diabetes, obesity, hypercholesterolemia, hyperlipidemia, dyslipidemia, hypertriglylceridemia, hyperglycemia, insulin resistance and hyperinsulinemia.

2. The method of claim 1 , wherein the subject is a human.

3. The method of claim 1 , wherein the administration is oral.

4. The method of claim 1 , wherein the administration is parenteral.

5. The method of claim 1 , wherein the administration is topical.

6. The method of claim 1 , wherein the metabolic disorder is mediated by PPARγ.

7. The method of claim 1 , wherein the compound is admininistered in the form of a pharmaceutical composition comprising the compound, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier or excipient.

8. The method of claim 7 , wherein the compound is in a unit dosage form.

9. The method of claim 8 , wherein the unit dosage form is a packaged preparation.

10. The method of claim 7 , wherein the pharmaceutical composition is a tablet, capsule, power, cachet, or lozenge.

11. The method of claim 7 , wherein the amount of the compound in the pharmaceutical composition is about 0.1 mg to about 100 mg.

12. The method of claim 11 , wherein the amount of the compound in the pharmaceutical composition is about 1.0 mg to about 100 mg.

13. The method of claim 8 , wherein the unit dosage form contains about 5% of the compound.

14. The method of claim 1 , wherein the compound is administered as a daily dose.

15. The method of claim 1 , wherein about 0.001 mg/kg to about 10 mg/kg of the compound is administered to the subject.

16. The method of claim 15 , wherein about 0.1 mg/kg to about 10 mg/kg of the compound is administered to the subject.