Nanoparticle fabrication methods, systems, and materials for fabricating artificial red blood cells
View Patent ↗A plurality of artificial red blood cell particles includes each particle of the plurality being substantially monodisperse and each particle having a largest common linear dimension of about 5 μm to about 10 μm. The particles can also have a modulus configured such that a particle of the plurality of particles can pass through a tube having an inner diameter of less than about 3 μm.
1. An artificial red blood cell comprising a substantially disc shaped, molded synthetic polymer particle having a largest linear dimension of between about 5 um to about 10 um and a modulus of less than about 1 MPa; and wherein the particle can pass through a tube having an inner diameter of less than about 3 um.
2. The artificial red blood cell of claim 1 , wherein said particle has a largest linear dimension of about 8 μm.
3. The artificial red blood cell of claim 1 , wherein said particle has a volume of about 98 μm 3 .
4. The artificial red blood cell of claim 1 , wherein said particle has a surface area of about 130 μm 2 .
5. The artificial red blood cell of claim 1 , wherein said particle is hydrophilic.
6. The artificial red blood cell of claim 1 , wherein said particle comprises poly(ethylene glycol).
7. The artificial red blood cell of claim 1 , wherein said particle comprises perfluoropolyether.
8. The artificial red blood cell of claim 1 , wherein said particle further comprises surface functionality selected from the group consisting of PEGylation, blood type antigens, and natural mimics.
9. The artificial red blood cell of claim 1 , wherein said particle further comprises a cargo selected from the group consisting of a therapeutic agent, hemoglobin, or an imaging agent.
10. The artificial red blood cell of claim 1 , wherein said particle further comprises a cargo and the cargo is capable of binding and releasing oxygen.