Compositions and methods for therapeutic delivery with frozen particles
Certain embodiments disclosed herein relate to compositions, methods, devices, systems, and products regarding frozen particles. In certain embodiments, the frozen particles include materials at low temperatures. In certain embodiments, the frozen particles provide vehicles for delivery of particular agents. In certain embodiments, the frozen particles are administered to at least one biological tissue.
1 .- 40 . (canceled)
41 . A method of providing at least one therapeutic agent to at least one biological tissue of a subject, comprising:
delivering at least one therapeutic composition to at least one biological tissue, including
one or more frozen solution particles including at least one therapeutic agent.
42 .- 44 . (canceled)
45 . The method of claim 41 , wherein delivering at least one therapeutic composition to at least one biological tissue includes propelling the therapeutic composition toward the at least one biological tissue.
46 . The method of claim 45 , wherein the at least one therapeutic composition is propelled to a predetermined pressure for delivery of the at least one therapeutic composition to a desired location of the at least one biological tissue.
47 . (canceled)
48 . The method of claim 45 , wherein the at least one therapeutic composition is propelled to a predetermined velocity for delivery of the at least one therapeutic composition to a desired location of the at least one biological tissue.
49 . (canceled)
50 . The method of claim 41 , wherein delivering at least one therapeutic composition includes ejecting the therapeutic composition toward at least one biological tissue.
51 . The method of claim 41 , wherein delivering at least one therapeutic composition includes accelerating the therapeutic composition toward at least one biological tissue.
52 .- 53 . (canceled)
54 . The method of claim 41 , wherein delivering at least one therapeutic composition to at least one biological tissue includes propelling, ejecting, or accelerating a plurality of therapeutic compositions toward at least one biological tissue.
55 .- 58 . (canceled)
59 . The method of claim 41 , wherein delivering the at least one therapeutic composition occurs prior to, during, or subsequent to surgery.
60 . The method of claim 41 , wherein the at least one biological tissue is located in at least one of in situ, in vitro, in vivo, in utero, in planta, in silico, or ex vivo.
61 . (canceled)
62 . The method of claim 60 , wherein the at least one biological tissue is transplanted or implanted into at least one subject.
63 . The method of claim 60 , wherein the at least one biological tissue is ingested by at least one subject.
64 . The method of claim 60 , wherein the at least one biological tissue includes at least one biological tissue from at least one donor or recipient.
65 . The method of claim 64 , wherein at least one donor includes at least one cadaver.
66 . (canceled)
67 . The method of claim 60 , wherein the at least one biological tissue includes at least one cell mass.
68 .- 71 . (canceled)
72 . The method of claim 41 , further comprising delivering to the at least one biological tissue at least one of a polymer, biopolymer, nanoparticle, or detection material.
73 .- 75 . (canceled)
76 . The method of claim 72 , wherein the detection material includes at least one electronic identification device.
77 . The method of claim 76 , wherein the at least one electronic identification device includes at least one radio frequency identification device.
78 . The method of claim 72 , wherein the detection material includes at least one radioactive element.
79 . (canceled)
80 . The method of claim 72 , wherein the detection material includes at least one calorimetric substance.
81 . (canceled)
82 . The method of claim 80 , wherein the at least one calorimetric substance includes one or more of a dye, pigment, or light-emitting substance.
83 .- 84 . (canceled)
85 . The method of claim 72 , wherein the detection material includes at least one of a diamagnetic particle, ferromagnetic particle, paramagnetic particle, super paramagnetic contrast agent, or other magnetic particle.
86 . The method of claim 41 t, wherein the subject includes at least one invertebrate or vertebrate animal.
87 . (canceled)
88 . The method of claim 41 , wherein the subject includes at least one human.
89 . The method of claim 86 , wherein the subject includes at least one of livestock, pet, undomesticated herd animal, wild animal, or a product animal.
90 .- 91 . (canceled)
92 . The method of claim 41 , wherein the at least one therapeutic composition further comprises one or more reinforcement agents.
93 . The method of claim 4 f, wherein the at least one therapeutic composition further comprises one or more explosive materials.
94 . A method of vaccinating a subject, comprising:
administering to a subject at least one therapeutic composition;
wherein the at least one therapeutic composition includes one or more frozen solution particles including at least one vaccine.
95 .- 96 . (canceled)
97 . The method of claim 94 , wherein the at least one vaccine includes at least one prophylactic or therapeutic vaccine.
98 . The method of claim 97 , wherein the at least one therapeutic vaccine includes at least one anti-cancer vaccine.
99 . (canceled)
100 . The method of claim 94 , further comprising at least one adjuvant.
101 .- 102 . (canceled)
103 . The method of claim 94 ; wherein administering to a subject at least one therapeutic composition includes delivering the at least one therapeutic composition to at least one biological tissue of the subject.
104 . The method of claim 103 ; wherein delivering at least one therapeutic composition to at least one biological tissue includes propelling the therapeutic composition toward the at least one biological tissue.
105 . The method of claim 104 , wherein the at least one therapeutic composition is propelled to a predetermined pressure for delivery of the at least one therapeutic composition to a desired location on or in the at least one biological tissue.
106 .- 108 . (canceled)
109 . The method of claim 103 , wherein delivering at least one therapeutic composition includes ejecting the therapeutic composition toward at least one biological tissue.
110 . The method of claim 103 , wherein delivering at least one therapeutic composition to at least one biological tissue includes accelerating the therapeutic composition toward at least one biological tissue.
111 .- 112 . (canceled)
113 . The method of claim 103 , wherein delivering at least one therapeutic composition to at least one biological tissue includes propelling, ejecting, or accelerating a plurality of therapeutic compositions toward the at least one biological tissue.
114 .- 117 . (canceled)
118 . The method of claim 103 , wherein delivering the at least one therapeutic composition occurs prior to, during, or subsequent to surgery.
119 . The method of claim 103 , wherein the at least one biological tissue is located in at least one of in situ, in vitro, in vivo, in utero, in planta, in silico, or ex vivo.
120 . (canceled)
121 . The method of claim 119 , wherein the at least one biological tissue is transplanted or implanted into at least one subject.
122 . The method of claim 119 , wherein the at least one biological tissue is ingested by at least one subject.
123 . The method of claim 119 , wherein the at least one biological tissue includes at least one biological tissue from at least one donor or recipient.
124 . The method of claim 123 , wherein at least one donor includes at least one cadaver.
125 . (canceled)
126 . The method of claim 119 , wherein the at least one biological tissue includes at least one cell mass.
127 .- 130 . (canceled)
131 . The method of claim 94 , further comprising delivering to the at least one biological tissue at least one of a polymer, biopolymer, nanoparticle, or detection material.
132 .- 134 . (canceled)
135 . The method of claim 131 , wherein the detection material includes at least one electronic identification device.
136 . The method of claim 135 , wherein the at least one electronic identification device includes at least one radio frequency identification device.
137 . The method of claim 131 , wherein the detection material includes at least one radioactive element.
138 . (canceled)
139 . The method of claim 13 − 1 , wherein the detection material includes at least one colorimetric substance.
140 .- 143 . (canceled)
144 . The method of claim 131 $ wherein the detection material includes at least one of a diamagnetic particle, ferromagnetic particle, paramagnetic particle, super paramagnetic contrast agent, or other magnetic particle.
145 . The method of claim 94 , wherein the subject includes at least one invertebrate or vertebrate animal.
146 . (canceled)
147 . The method of claim 94 , wherein the subject includes at least one human.
148 . The method of claim 145 , wherein the subject includes at least one of livestock, pet, undomesticated herd animal, wild animal, or a product animal.
149 .- 150 . (canceled)
151 . The method of claim 94 , wherein the at least one therapeutic composition further comprises one or more reinforcement agents.
152 . The method of claim 94 , wherein the at least one therapeutic composition further comprises one or more explosive materials.