Compositions and methods for delivery of frozen particle adhesives
View Patent ↗Certain embodiments disclosed herein relate to compositions, methods, devices, systems, and products regarding frozen particles. In certain embodiments, the frozen particles include materials at low temperatures. In certain embodiments, the frozen particles provide vehicles for delivery of particular agents. In certain embodiments, the frozen particles are administered to at least one biological tissue.
1. A method for providing at least one adhesive agent to at least one substrate, comprising:
administering at least one frozen particle composition to at least one substrate at a predetermined velocity, wherein the at least one frozen particle composition includes one or more frozen hydrogen oxide particles coated in at least one adhesive agent; wherein the at least one adhesive agent includes one or more epoxy adhesive, acrylic adhesive, urethane adhesive, polyurethane adhesive, anerobic adhesive, urethane acrylate, polyester acrylate, methyacrylate, or cyanoacrylate.
2. The method of claim 1 , wherein the at least one adhesive agent includes at least one of a monomer, prepolymer, polymer, or copolymer.
3. The method of claim 1 , wherein the substrate includes at least a portion of which is naturally, artificially, or synthetically derived.
4. The method of claim 1 , wherein the substrate includes at least a portion of which is genetically altered.
5. The method of claim 1 , wherein the at least one substrate includes one or more of a cell, tissue, organ, structure, or device.
6. The method of claim 5 , wherein the structure includes one or more of a prosthesis, cell matrix, or tissue matrix.
7. The method of claim 1 , wherein the at least one substrate is located in at least one of in situ, in vitro, in vivo, in utero, in planta, or ex vivo.
8. The method of claim 7 , wherein the at least one substrate is transplanted or implanted into at least one subject.
9. The method of claim 7 , wherein the at least one substrate is ingested by at least one subject.
10. The method of claim 7 , wherein the at least one substrate includes at least one biological tissue from at least one donor or recipient.
11. The method of claim 1 , wherein the at least one substrate includes one or more wounds.
12. The method of claim 1 , further including varying the rate, velocity, or angle at which the at least one frozen particle composition is administered to at least one substrate.
13. The method of claim 1 , further including administering to the at least one substrate at least one of a nanoparticle, detection material, sensor, micro-syringe, or circuit.
14. The method of claim 1 , wherein the at least one frozen particle composition further includes one or more of a reinforcement agent, abrasive, explosive material, or biological remodeling agent.
15. The method of claim 1 , wherein the at least one adhesive agent further includes at least one α-cyanoacrylate and a fluorescent compound including at least one of a bis-benzoxazolyl compound, pyrylium salt, quantum dot, or coumarin compound.
16. The method of claim 1 , wherein the at least one adhesive agent further includes an α-cyanoacrylate and 2,5-bis-(5-tert-butyl-2-benzoxasolyl)-thiophene.
17. The method of claim 1 , wherein the at least one adhesive agent further includes one or more of a base component, initiator component, or activator component.
18. The method of claim 1 , wherein the at least one adhesive agent further includes at least one curing component.
19. A method of maintaining the approximation of tissue of at least one wound of a subject, comprising:
administering at least one frozen particle composition to at least one wound of a subject at a predetermined velocity, for a time sufficient to maintain the approximation of tissue of the at least one wound;
wherein the at least one frozen particle composition includes one or more frozen hydrogen oxide coated in at least one adhesive agent; wherein the at least one adhesive agent; wherein the at least one adhesive agent includes one or more epoxy adhesive, acrylic adhesive, urethane adhesive, polyurethane adhesive, anerobic adhesive, urethane acrylate, polyester acrylate, methyacrylate, or cyanoacrylate; and
wherein the one or more frozen hydrogen oxide particles have one or more phases including at least one of amorphous solid water, low density amorphous ice, high density amorphous ice, very high density amorphous ice, clathrate ice, hyperquenched glassy water, ice Ic, ice II, ice III, ice IV, ice V, ice VI, ice VII, ice VIII, ice IX, ice X, ice XI, ice XII, ice XIII, ice XIV, or ice XV.