IP Library › Patent Application 12383634
Patent Application
App. No. 12/383,634

Rhesus monkey Nur77

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Quick Facts
Patent No.
US None
App. No.
12/383,634
Abstract

The Macaca mulatta (rhesus monkey) Nur77 (rhNur77) nuclear receptor and the nucleic acid encoding the rhNur77 nuclear receptor are described. Further described are methods for identifying analytes that modulate expression or activity of the rhNur77 nuclear receptor. Analytes that affect Nur77 expression or activity may be used to treat or inhibit inflammatory diseases, for example, osteoarthritis and various bone, neurological, and prostrate disorders. The rhNur77 may also be used to treat various cancers, for example, prostate, ovarian, colon, lung, and gastric cancer.

Claims (8)

1 . (canceled)

2 . (canceled)

3 . An isolated rhesus monkey Nur77 polypeptide comprising amino acids having the sequence set forth in SEQ ID NO: 2 or a fragment thereof.

4 .- 17 . (canceled)

18 . The isolated rhesus monkey Nur77 polypeptide of claim 1 , wherein the polypeptide comprises amino acids 332 to 566 of SEQ ID NO: 2.

19 . The isolated rhesus monkey Nur77 polypeptide of claim 1 , wherein the polypeptide comprises amino acids 265 to 332 of SEQ ID NO: 2.

20 . The isolated rhesus monkey Nur77 polypeptide of claim 1 , wherein the polypeptide comprises amino acids 332 to 598 of SEQ ID NO: 2.

21 . The isolated rhesus monkey Nur77 polypeptide of claim 1 , wherein amino acid 479 of SEQ ID NO: 2 is a leucine.

Assignments (2)
CHANGE OF NAME Recorded Nov 24, 2009
From: MERCK & CO., INC
To: MERCK SHARP & DOHME CORP.
Reel/Frame 023563/0437 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 27, 2009
From: GAMBONE, CARLO J.; SCHMIDT, AZRIEL
To: MERCK & CO., INC.
Reel/Frame 022499/0905 →