Particle immobilized coatings and uses thereof
View Patent ↗Surface coatings including microparticles immobilized in a matrix of polymeric material on a substrate are described. The microparticles can also include an agent which can be useful for various applications, such as medical applications. This invention relates to the field of surface coatings for use in various applications. More particularly, the invention relates to surface coating useful for drug delivery, imaging and other uses of microparticles immobilized via a polymeric matrix.
1. An implantable medical device comprising:
a) a surface;
b) a matrix comprising polymeric material, the matrix polymeric material comprising a hydrophobic polymer, copolymer or combinations thereof, and one or more photoreative groups covalently attached to the matrix polymeric material, and wherein the matrix polymeric material is covalently attached to the surface by the photoreactive groups; and
c) a plurality of microparticles immobilized in the matrix of polymeric material, wherein the microparticles comprise a biologically active agent, and the microparticles are 100 nm to 20 μm in diameter, and wherein the biologically active agent is released from the matrix in the presence of a fluid-containing environment.
2. The implantable medical device of claim 1 that is an intravascular catheter.
3. The implantable medical device of claim 1 wherein the surface comprises a balloon.
4. The implantable medical device of claim 1 wherein the microparticles comprise an antiproliferative agent.
5. The implantable medical device of claim 1 wherein some microparticles are associated with the matrix although not completely surrounded by polymeric material.
6. The implantable medical device of claim 1 wherein the microparticles are degradable.
7. The implantable medical device of claim 1 wherein the microparticles are formed by solvent evaporation.
8. The implantable medical device of claim 1 wherein the photoreactive group is selected from the group consisting of aryl ketones, arylazides, acyl azides, sulfonyl azides, phosphoryl azides, diazoalkanes, diazoketones, diazoacetates, and ketenes.
9. The implantable medical device of claim 1 wherein the polymer, copolymer, or combinations thereof, comprises a synthetic hydrophobic polymer.
10. The implantable medical device of claim 9 wherein the polymer, copolymer, or combinations thereof, is selected from the group consisting of polyacrylamide, polymethacrylamide, polyvinylpyrrolidone, polyacrylic acid, polyethylene glycol, polyvinyl alcohol, and poly(HEMA), copolymers thereof, and combinations thereof.
11. The implantable medical device of claim 1 wherein the microparticles are immobilized in the matrix by entrapment, wherein the entrapment of the microparticles does not depend on the formation of ionic or covalent bonds between the microparticles and the polymeric material.
12. The implantable medical device of claim 1 wherein the matrix has a thickness and the microparticles have a diameter and the thickness of the layer is greater than the diameter of the microparticles.
13. The implantable medical device of claim 1 wherein a plurality of compounds smaller than the microparticles are diffusible in the matrix of polymeric material.
14. The implantable medical device of claim 1 wherein the matrix comprises a polymer crosslinking compound.
15. The implantable medical device of claim 14 wherein the polymer crosslinking compound comprises at least one photoactivatable group.
16. The implantable medical device of claim 1 formed by disposing a polymer comprising photoreactive groups on the surface, treating the polymer to form the matrix, and then disposing the plurality of microparticles on the matrix, wherein the microparticles become immobilized in the matrix.