Compositions and methods for administering compartmentalized frozen particles
View Patent ↗Certain embodiments disclosed herein relate to compositions, methods, devices, systems, and products regarding frozen particles. In certain embodiments, the frozen particles include materials at low temperatures. In certain embodiments, the frozen particles provide vehicles for delivery of particular agents. In certain embodiments, the frozen particles are administered to at least one biological tissue.
1. A frozen particle composition, comprising:
a non-hydrogen oxide frozen solvent particle of at least one of acetone, ethyl acetate, dimethyl formamide, dioxane, tetrahydrofuran, acetronitrile, hexamethylphosphorotriamide, tert-butyl alcohol, formic acid, hydrogen fluoride, ammonia, benzene, carbon tetrachloride, acetonitrile, hexane, dichloromethane, methylene chloride, methane, toluene, chloroform, or diethyl ether defining at least one cavity; and
the at least one cavity containing at least one agent including at least one abrasive, toxic agent.
2. The frozen particle composition of claim 1 , wherein the non-hydrogen oxide frozen solvent particle further comprises at least one of polyethylene glycol, Ringer's solution, lactated Ringer's solution, Hartmann's solution, acetated Ringer's solution, phosphate buffered solution, TRIS-buffered saline solution, Hank's balanced salt solution, Earle's balanced salt solution, HEPES-buffered saline, dextrose, or glucose.
3. The frozen particle composition of claim 1 , wherein at least one cavity is configured to physically or chemically separate the at least one agent from at least one other cavity of the frozen solvent particle.
4. The frozen particle composition of claim 1 , wherein the at least one cavity is an inner core cavity of at least one frozen solvent particle.
5. The frozen particle composition of claim 1 , wherein the at least one cavity has a higher concentration of the at least one agent than any other cavity.
6. The frozen particle composition of claim 1 , wherein the at least one cavity includes one or more layers of at least one agent.
7. The frozen particle composition of claim 1 , wherein the at least one agent includes one or more of a pro-drug or precursor compound.
8. The frozen particle composition of claim 1 , wherein the at least one agent includes one or more time-release or extended-release formulations.
9. The frozen particle composition of claim 1 , further including at least one of a nanoparticle, detection material, sensor, micro-syringe, or circuit.
10. The frozen particle composition of claim 9 , wherein the detection material is intermixed with the at least one frozen particle composition.
11. The frozen particle composition of claim 9 , wherein the detection material is located in the at least one frozen particle composition.
12. The frozen particle composition of claim 9 , wherein the detection material is located in at least one cavity of at least one frozen particle composition.
13. The frozen particle composition of claim 9 , wherein the detection material includes at least one electronic identification device.
14. The frozen particle composition of claim 13 , wherein the at least one electronic identification device includes at least one radio frequency identification device.
15. The frozen particle composition of claim 9 , wherein the detection material includes at least one radioactive element.
16. The frozen particle composition of claim 15 , wherein the at least one radioactive element includes one or more of 32 P, 35 S, 13 C, 131 I, 191 Ir, 192 I, 193 Ir, or 3 H.
17. The frozen particle composition of claim 9 , wherein the detection material includes at least one luminescent, colorimetric or odorous substance.
18. The frozen particle composition of claim 17 , wherein the at least one colorimetric substance includes one or more of an inorganic, organic, biological, natural, artificial, or synthetic substance.
19. The frozen particle composition of claim 9 , wherein the at least one detection material includes one or more of a dye, pigment, luminescent substance, fluorescent substance, or phosphorescent substance.
20. The frozen particle composition of claim 9 , wherein the detection material includes at least one of a diamagnetic particle, ferromagnetic particle, paramagnetic particle, super paramagnetic contrast agent, or other magnetic particle.
21. A frozen particle composition, comprising:
a non-hydrogen oxide frozen solvent particle of at least one of acetone, ethyl acetate, dimethyl formamide, dioxane, tetrahydrofuran, acetronitrile, hexamethylphosphorotriamide, tert-butyl alcohol, formic acid, hydrogen fluoride, ammonia, benzene, carbon tetrachloride, acetonitrile, hexane, dichloromethane, methylene chloride, methane, toluene, chloroform, or diethyl ether defining at least one cavity; and
the at least one cavity containing at least one agent including Botulinum toxin.