Compositions and methods for administering compartmentalized frozen particles
View Patent ↗Certain embodiments disclosed herein relate to compositions, methods, devices, systems, and products regarding frozen particles. In certain embodiments, the frozen particles include materials at low temperatures. In certain embodiments, the frozen particles provide vehicles for delivery of particular agents. In certain embodiments, the frozen particles are administered to at least one biological tissue.
1. A frozen particle composition, comprising:
a frozen saline solution particle defining at least one cavity;
the at least one cavity containing at least one cytokine encapsulated in a liposome; and
wherein the frozen solution particle is a frozen water and saline solution; and
wherein the frozen solution particle is coated in at least one of collagenase, elastase, collagen, keratin, elastin, fibrin, heparin, or fibrinogen, and is approximately one nanometer or less.
2. The frozen particle composition of claim 1 , wherein the frozen solution particle is in one or more phases including at least one of amorphous solid water, low density amorphous ice, high density amorphous ice, very high density amorphous ice, clathrate ice, hyperquenched glassy water, ice Ic, ice Ih, ice II, ice III, ice IV, ice V, ice VI, ice VII, ice VIII, ice IX, ice X, ice XI, ice XII, ice XIII, or ice XIV.
3. The frozen particle composition of claim 1 , wherein the at least one cavity includes at least one matrix.
4. The frozen particle composition of claim 1 , wherein the at least one cavity is an inner core cavity of at least one frozen solution particle.
5. The frozen particle composition of claim 1 , wherein the at least one cavity has a higher concentration of the at least one agent than any other cavity.
6. The frozen particle composition of claim 1 , wherein the at least one cavity includes one or more layers of at least one agent.
7. The frozen particle composition of claim 1 , wherein the at least one cavity includes one or more layers of multiple agents.
8. The frozen particle composition of claim 1 , wherein the at least one agent includes one or more of a pro-drug or precursor compound.
9. The frozen particle composition of claim 1 , wherein the at least one agent includes one or more time-release or extended-release formulations.
10. The frozen particle composition of claim 1 , wherein the at least one agent includes one or more of an adhesive agent, reinforcement agent, abrasive, therapeutic agent, biological remodeling agent, or explosive material.
11. The frozen particle composition of claim 1 , further comprising a plurality of frozen solution particles that are approximately uniform in size, shape, weight, or density.
12. The frozen particle composition of claim 1 , further including at least one of a nanoparticle, detection material, sensor, micro-syringe, or circuit.
13. The frozen particle composition of claim 12 , wherein the detection material is intermixed with the at least one frozen particle composition.
14. The frozen particle composition of claim 12 , wherein the detection material is located in the at least one frozen particle composition.
15. The frozen particle composition of claim 12 , wherein the detection material is located in at least one cavity of at least one frozen particle composition.
16. The frozen particle composition of claim 12 , wherein the detection material includes at least one electronic identification device.
17. The frozen particle composition of claim 16 , wherein the at least one electronic identification device includes at least one radio frequency identification device.
18. The frozen particle composition of claim 12 , wherein the detection material includes at least one radioactive element.
19. The frozen particle composition of claim 18 , wherein the at least one radioactive element includes one or more of 32 P, 35 S, 13 C, 131 I, 191 Ir, 192 Ir, 193 Ir, or 3 H.
20. The frozen particle composition of claim 12 , wherein the detection material includes at least one luminescent, colorimetric or odorous substance.
21. The frozen particle composition of claim 20 , wherein the at least one colorimetric substance includes one or more of an inorganic, organic, biological, natural, artificial, or synthetic substance.
22. The frozen particle composition of claim 12 , wherein the at least one detection material includes one or more of a dye, pigment, luminescent substance, fluorescent substance, or phosphorescent substance.
23. The frozen particle composition of claim 12 , wherein the detection material includes at least one of a diamagnetic particle, ferromagnetic particle, paramagnetic particle, super paramagnetic contrast agent, or other magnetic particle.