Double compartment skincare products comprising avermectin/milbemycin compounds

1. A single pack skincare product having two compartments:

(a) a first compartment containing a first anhydrous composition comprising, in a pharmaceutically acceptable medium, an active ingredient which is ivermectin in a form which is solubilized in a member selected from the group consisting of polar solvents, oils, amphiphilic solvents and their mixtures, said first anhydrous composition being a solution or an anhydrous gel comprising at least, in percent by weight relative to the total weight of the composition:

(i) from 0.1 to 99.99% of at least one polar solvent for the active ingredient;

(ii) gelling agent(s) in an amount of up to 5%;

(iii) from 0 to 10% of surfactant(s);

(iv) from 0.001 to 50% of active ingredient; and

(v) from 0 to 3% of preservative(s), and

(b) a second compartment containing a second composition comprising pharmaceutically and/or cosmetically acceptable excipients and which comprise at least a moisturizing compound and/or emollient,

as a combination product useful for the treatment of dermatological conditions/afflictions simultaneously, separately or spread out over time, wherein the first and second compartments are the only compartments in the skincare product, and wherein the single pack skincare product is to be marketed.

2. The skincare product as defined by claim 1 , wherein the first anhydrous composition comprises from 0.01% to 15% by weight of ivermectin.

3. The skincare product as defined by claim 1 , wherein the first anhydrous composition comprises an anhydrous gel or a simple anhydrous solution.

4. The skincare product as defined by claim 1 , wherein the second composition is anhydrous.

5. The skincare product as defined by claim 1 , wherein the second composition comprises an anhydrous emulsion.

6. The skincare product as defined by claim 5 , wherein the second composition comprises an anhydrous emulsion including at least

8 to 40% of oil;

0.5 to 8% of emulsifier(s) having a hydrophilic-lipophilic balance (HLB) ranging between 2 and 7;

0 to 5% of coemulsifier(s) having an HLB greater than 6;

0 to 8% of gelling agent(s);

0 to 60% of humectant(s);

0 to 5% of purified water; and

0 to 3% of preservative(s).

7. The skincare product as defined by claim 4 , wherein the second composition comprises an anhydrous gel.

8. The skincare product as defined by claim 7 , wherein the second composition comprises an anhydrous gel including at least:

4 to 95% of silicone elastomer;

2 to 20% of oil(s); and

0 to 20% of thickener(s).

9. The skincare product as defined by claim 1 , wherein the second composition is aqueous.

10. The skincare product as defined by claim 9 , wherein the second composition comprises an aqueous emulsion.

11. The skincare product as defined by claim 10 , wherein the second composition comprises a gel cream including at least:

4 to 60% of oily phase;

0.3 to 2% of polymeric emulsifier(s);

0 to 2% of gelling agent(s);

0 to 4% of coemulsifier(s);

30 to 90% of purified water; and

0 to 3% of preservative(s).

12. The skincare product as defined by claim 10 , wherein the second composition comprises an oil-in-water emulsion including at least:

50 to 70% of aqueous phase;

0 to 10% of emulsifier(s);

0 to 4% of thickener(s);

0.05 to 1% of gelling agent(s);

0 to 20% of humectant(s); and

0 to 3% of preservative(s).

13. The skincare product as defined by claim 9 , wherein the second composition comprises an aqueous gel.

14. The skincare product as defined by claim 13 , wherein the second composition comprises an aqueous gel including at least:

50 to 99.7% of purified water;

0.3 to 2% of gelling agent(s);

0 to 20% of humectant(s); and

0 to 3% of preservative(s).

15. The skincare product as defined by claim 1 , wherein the second composition comprises at least one active ingredient.

16. A method for the treatment of a dermatological condition or affliction selected from the group consisting of rosacea, acne vulgaris, seborrhoeic dermatitis, perioral dermatitis, acneform rash, transient acantholytic dermatitis and acne miliaris riecrotica, said method comprising topically applying to the skin of a subject in need of such treatment the skincare product as defined by claim 1 .

17. The method as defined by claim 16 , said dermatological condition/affliction being rosacea.