Piperazine derivatives
View Patent ↗This invention relates to novel compounds that are piperazine derivatives, and pharmaceutically acceptable salts thereof. More specifically, the invention relates to novel piperazine compounds that are derivatives of the chemokine CCR5 receptor antagonist, vicriviroc. This invention also provides pyrogen-free compositions comprising one or more compounds of the invention and a carrier and the use of the disclosed compounds and compositions in methods of treating diseases and conditions that are treated by administering chemokine CCR5 receptor antagonists, such as vicriviroc. The invention also relates to the use of one or more of the disclosed compounds as reagents in analytical studies involving vicriviroc.
1. A compound selected from any one of the compounds set forth below:
or a pharmaceutically acceptable salt of any of the foregoing.
2. A pyrogen-free pharmaceutical administration comprising a compound of claim 1 or a pharmaceutically acceptable salt thereof; and a pharmaceutically acceptable carrier.
3. The composition of claim 2 comprising a second therapeutic agent selected from an HIV protease inhibitor, a NNRTI, a NRTI, a second viral entry inhibitor, an integrase inhibitor, an immune based antiretroviral agent, a viral maturation inhibitor, or a combination of two or more of the foregoing.
4. The composition of claim 3 , wherein the second therapeutic agent is selected from emtricitabine, tenofovir disoproxil fumarate, ritonavir, lamivudine, zidovudine, tipranavir, enfuvirtide and ancriviroc.
5. The composition of claim 4 , wherein the second therapeutic agent is selected from ritonavir, lamivudine, emtricitabine, tenofovir disoproxil fumarate, and zidovudine.
6. A method of treating an HIV—1 infection in a patient comprising the step of administering to the patient an effective amount of a compound of claim 1 or a pharmaceutically acceptable salt thereof.
7. The method of claim 6 comprising the additional step of co-administering to the patient in need thereof a second therapeutic agent selected from one or more of an HIV protease inhibitor, a NNRTI, a NRTI, a second viral entry inhibitor, an integrase inhibitor, an immune based antiretroviral agent, and a viral maturation inhibitor.
8. The method of claim 7 , wherein the second therapeutic agent is selected from one or more of emtricitabine, tenofovir disoproxil fumarate, ritonavir, lamivudine, zidovudine, tipranavir, enfuvirtide and ancriviroc.
9. The method of claim 8 , wherein the second therapeutic agent is selected from emtricitabine and tenofovir disoproxil fumarate.
10. A compound of claim 1 , wherein any atom not designated as deuterium is present at its natural isotopic abundance.