Sphingosine kinase type 1 inhibitors, compositions and processes for using same
View Patent ↗Provided are novel compositions which uniquely inhibit sphingosine kinase Type 1 (SphK1) and which are useful in a number of applications including killing or damaging cancer cells, inducing apoptosis, inhibiting growth, metastasis and development of chemoresistance in cancer cells, leukemia, increasing the effectiveness of anti-cancer agents, attenuating immune reactivity, inhibiting survival signaling in cancer cells, and reducing symptoms of multiple sclerosis.
1. A compound
2. A composition comprising the compound of claim 1 , wherein the composition inhibits sphingosine kinase 1 (SphK1) at least five times greater than it inhibits sphingosine kinase 2 (SphK2) in an in vitro assay that measures sphingosine kinase activity.
3. A pharmaceutical composition comprising the compound of claim 1 .
4. A compound
5. A pharmaceutical composition comprising the compound of claim 4 .