Ex VIVO modifiable particle or polymeric material medicament carrier
Described embodiments include a final dosage form, an article of manufacture, and method. A final dosage form for administering a medicament to an animal is described. The final dosage form includes the medicament. The final dosage form also includes a particle or polymeric material carrying the medicament in a first medicament-release state wherein the medicament is available to the animal in a first bioavailability if the final dosage form is administered to the animal. The particle or polymeric material is modifiable ex vivo by an exposure to a stimulus to carry the medicament in a second medicament-release state wherein the medicament is available to the animal in a second bioavailability if the final dosage form is administered to the animal. In an embodiment, the final dosage form further includes a transport medium suitable for delivering the particle or polymeric material binding the medicament to the animal.
1 . A final dosage for administering a medicament to an animal, the final dosage form comprising:
the medicament; and
a particle or polymeric carrying the medicament in a first medicament-release state wherein the medicament is available to the animal in a first bioavailability if the final dosage form is administered to the animal,
the particle or polymeric modifiable ex vivo by an exposure to a stimulus to carry the medicament in a second medicament-release state wherein the medicament is available to the animal in a second bioavailability if the final dosage form is administered to the animal.
2 . The final dosage form of claim 1 , wherein the first bioavailability to the animal includes a first bioavailability characteristic to the animal and the second bioavailability to the animal includes a second bioavailability characteristic.
3 . The final dosage form of claim 2 , wherein the second bioavailability to the animal includes a substantially different bioavailability to the animal than the first bioavailability to the animal.
4 . The final dosage form of claim 2 , wherein the first bioavailability characteristic to the animal includes a first medicament dosage and the second bioavailability characteristic to the animal includes a second medicament dosage.
5 . The final dosage form of claim 2 , wherein the first bioavailability characteristic to the animal includes a first medicament release kinetic and the second bioavailability characteristic to the animal includes a second medicament release kinetic.
6 . The final dosage form of claim 2 , wherein the first bioavailability characteristic to the animal includes a first medicament release profile and the second bioavailability characteristic to the animal includes a second medicament release profile.
7 . The final dosage form of claim 2 , wherein the first bioavailability characteristic to the animal includes a first medicament release rate and the second bioavailability characteristic to the animal includes a second medicament release rate.
8 . The final dosage form of claim 2 , wherein the first bioavailability characteristic to the animal includes a first medicament release delay time and the second bioavailability characteristic to the animal includes a second medicament release delay time.
9 . The final dosage form of claim 2 , wherein the first bioavailability characteristic to the animal includes a first medicament release pH dependence and the second bioavailability characteristic to the animal includes a second medicament release pH dependence.
10 . The final dosage form of claim 1 , wherein the particle or polymeric carrying the medicament includes:
an inert particle or polymeric carrying the medicament.
11 . The final dosage form of claim 1 , wherein the particle or polymeric carrying the medicament includes:
a particle or polymeric carrying the medicament in an association.
12 . The final dosage form of claim 1 , wherein the particle or polymeric carrying the medicament includes:
a particle or polymeric encapsulating the medicament.
13 . The final dosage form of claim 1 , wherein the particle or polymeric carrying the medicament includes:
a particle or polymeric encompassing the medicament.
14 . The final dosage form of claim 1 , wherein the particle or polymeric carrying the medicament includes:
a particle or polymeric at least one of engaging, retaining, or binding the medicament.
15 . The final dosage form of claim 1 , wherein the particle or polymeric carrying the medicament includes:
a particle or polymeric carrier conjugated with the medicament.
16 . The final dosage form of claim 1 , wherein the particle or polymeric carrying the medicament includes:
the medicament taken-up by the particle or polymeric.
17 . The final dosage form of claim 1 , further comprising:
a transport medium suitable for delivering the particle or polymeric binding the medicament to the animal.
18 . The final dosage form of claim 1 , further comprising:
an indicator substance associated with the particle or polymeric and configured to indicate an exposure to the stimulus of the particle or polymeric carrying the medicament.
19 . A final dosage form for administering medicament to an animal, wherein the final dosage form comprises:
a dosage portion carrying a medicament in a first medicament-release state wherein the medicament is bioavailable to the animal if the final dosage form is administered to the animal; and
another dosage portion carrying another medicament and including a release element in a first medicament-release state wherein the another medicament has a first bioavailability to the animal if the final dosage form is administered to the animal in the first medicament-release state,
the release element modifiable ex vivo to a second medicament-release state by an exposure to a stimulus, wherein the another medicament has a second bioavailability to the animal if the final dosage form is administered to the animal in the second medicament-release state.
20 . A method involving a final dosage form for administering medicament to an animal, wherein the final dosage form includes
a medicament, and
a particle or polymeric carrying the medicament in a first medicament-release state wherein the medicament is available to the animal in a first bioavailability if the final dosage form is administered to the animal,
the particle or polymeric modifiable ex vivo by an exposure to a stimulus to carry the medicament in a second medicament-release state wherein the medicament is available to the animal in a second bioavailability if the final dosage form is administered to the animal,
the method comprising:
transforming the particle or polymeric to the second medicament-release state by initiating an ex vivo exposure of the particle or polymeric to the stimulus.
21 . An article of manufacture for administering medicament to an animal, the article comprising:
means for releasably encompassing a medicament in a first state wherein the medicament is available to the animal in a first bioavailability if the final dosage form is administered to the animal,
the means for releasably encompassing the medicament in a first state modifiable ex vivo by an exposure to a stimulus to releasably encompass the medicament in a second state wherein the medicament is available to the animal in a second bioavailability if the final dosage form is administered to the animal; and
the medicament.