IP Library › Patent Application 12389235
Patent Application
App. No. 12/389,235

TARGETED THERAPEUTIC PROTEINS

Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US None
App. No.
12/389,235
Abstract

Targeted therapeutics that localize to a specific subcellular compartment such as the lysosome are provided. The targeted therapeutics include a therapeutic agent and a targeting moiety that binds a receptor on an exterior surface of the cell, permitting proper subcellular localization of the targeted therapeutic upon internalization of the receptor. Nucleic acids, cells, and methods relating to the practice of the invention are also provided.

Claims (4)

1 . A targeted therapeutic comprising:

a therapeutic agent that is therapeutically active in a mammalian lysosome; and

means for binding an extracellular domain of human cation-independent mannose-6-phosphate receptor in a mannose-6-phosphate-independent manner.

2 - 57 . (canceled)

Assignments (6)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 22, 2011
From: ZYSTOR THERAPEUTICS, INC.
To: BIOMARIN PHARMACEUTICAL INC.
Reel/Frame 025846/0079 →
CORRECTIVE ASSIGNMENT TO CORRECT THE SERIAL NUMBER 10/272,483 PREVIOUSLY RECORDED ON REEL 022326 FRAME 0958. ASSIGNOR(S) HEREBY CONFIRMS THE 12/389,235. Recorded Apr 21, 2009
From: LEBOWITZ, JONATHAN H.; BEVERLEY, STEPHEN M.
To: SYMBIONTICS, INC.
Reel/Frame 022576/0013 →
CORRECTIVE ASSIGNMENT TO CORRECT THE SERIAL NUMBER 10/272,483 PREVIOUSLY RECORDED ON REEL 022327 FRAME 0024. ASSIGNOR(S) HEREBY CONFIRMS THE SERIAL NUMBER 12/389,235. Recorded Apr 21, 2009
From: SYMBIONTICS INC.
To: SYMBIONTICS ACQUISITION CORP.
Reel/Frame 022576/0067 →
CORRECTIVE CHANGE OF NAME TO CORRECT THE SERIAL NUMBER 10/272,483 PREVIOUSLY RECORDED ON REEL 022327 FRAME 0207. ASSIGNOR(S) HEREBY CONFIRMS THE SERIAL NUMBER 12/389,235 Recorded Apr 21, 2009
From: SYMBIONTICS ACQUISITION CORP.
To: ZYSTOR THERAPEUTICS, INC.
Reel/Frame 022576/0147 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 27, 2009
From: LEBOWITZ, JONATHAN H.; BEVERLEY, STEPHEN M.
To: SYMBIONTICS, INC.
Reel/Frame 022326/0958 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 27, 2009
From: SYMBIONTICS INC.
To: SYMBIONTICS ACQUISITION CORP.
Reel/Frame 022327/0024 →