IP Library › Granted Patent US 8,008,445
Granted Patent B2
US 8,008,445 · App. 12/396,740 · Granted Aug 30, 2011

Metalloproteinase 9 binding proteins

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Quick Facts
Patent No.
US 8,008,445
App. No.
12/396,740
Granted
Aug 30, 2011
Kind
B2
Abstract

Proteins that bind to matrix metalloproteinase 9 and methods of using such proteins are described.

Claims (4)

1. An isolated antibody that binds to human Matrix Metalloproteinase-9 (MMP-9), wherein the antibody comprises a heavy chain variable domain comprising a HC-CDR1 comprising the amino acid sequence of SEQ ID NO: 956, a HC-CDR2 comprising the amino acid sequence of SEQ ID NO: 957, a HC-CDR3 comprising the amino acid sequence of SEQ ID NO: 958, and a light chain variable region comprising an LC-CDR1 comprising the amino acid sequence of SEQ ID NO: 953, a LC-CDR2 comprising the amino acid sequence of SEQ ID NO: 954, and a LC-CDR3 region comprising the amino acid sequence of SEQ ID NO: 955.

2. An anti-MMP-9 antibody-drug conjugate, wherein the conjugate comprises the isolated antibody of claim 1 and a drug.

3. The conjugate of claim 2 , wherein the drug is a cytotoxic or cytostatic agent.

4. A composition comprising the isolated antibody of claim 1 and a pharmaceutically acceptable carrier.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 18, 2021
From: DYAX CORP.
To: TAKEDA PHARMACEUTICAL COMPANY LIMITED
Reel/Frame 056268/0983 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 24, 2009
From: DEVY, LAETITIA; BUCKLER, DAVID; COHEN, EDWARD H.
To: DYAX CORP.
Reel/Frame 022444/0163 →