IP Library Granted Patent US 8,565,372
Granted Patent B2
US 8,565,372 · App. 12/397,013 · Granted Oct 22, 2013

System and method for low dose tomosynthesis

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Quick Facts
Patent No.
US 8,565,372
App. No.
12/397,013
Granted
Oct 22, 2013
Kind
B2
Abstract

A breast imaging system leverages the combined strengths of two-dimensional and three-dimensional imaging to provide a breast cancer screening with improved sensitivity, specificity and patient dosing. A tomosynthesis system supports the acquisition of three-dimensional images at a dosage lower than that used to acquire a two-dimensional image. The low-dose three-dimensional image may be used for mass detection, while the two-dimensional image may be used for calcification detection. Obtaining tomosynthesis data at low dose provides a number of advantages in addition to mass detection including the reduction in scan time and wear and tear on the x-ray tube. Such an arrangement provides a breast cancer screening system with high sensitivity and specificity and reduced patient dosing.

Claims (19)

1. A tomosynthesis breast imaging system comprising:

an x-ray source configured to move along an arc; and

an x-ray detector;

wherein the x-ray source and x-ray detector are configured to acquire a two-dimensional image and a three-dimensional image, wherein the two-dimensional image is acquired at a first dose and the three-dimensional image is acquired at a second dose less than or equal to the first dose, and wherein acquisition of the two-dimensional image is separate from acquisition of the three-dimensional image such that the x-ray source moves along the arc for the acquisition of the three-dimensional image.

2. The tomosynthesis breast imaging system of claim 1 wherein the second dose is a multiple of 0.25 to 1.0 of the first dose.

3. The tomosynthesis breast imaging system of claim 1 wherein the second dose is a multiple of 0.25 to 0.75 of the first dose.

4. The tomosynthesis breast imaging system of claim 1 wherein the second dose is half of the first dose.

5. The tomosynthesis breast imaging system of claim 1 wherein the first and second dose are controlled by varying at least one of a voltage, current, filter and exposure time of the x-ray source.

6. The tomosynthesis breast imaging system of claim 1 wherein the first and second dose are controlled by varying at least one of a scan angle and a number of projection images of a tomosynthesis exposure.

7. The tomosynthesis breast imaging system of claim 1 wherein the first and second dose are selected according to a mode of operation of the tomosynthesis breast imaging system.

8. An integrated mammography/tomosynthesis breast imaging system comprising:

an x-ray source; and

an x-ray detector;

wherein the x-ray source and x-ray detector are configured to acquire a mammogram and a plurality of tomosynthesis projection images, wherein the plurality of tomosynthesis projection images are acquired at a tomosynthesis dose that is less than a mammogram dose used to acquire the mammogram, and wherein acquisition of the mammogram is separate from acquisition of the plurality of tomosynthesis projection images such that the x-ray source moves along the arc for the acquisition of the plurality of tomosynthesis projection images.

9. A method of imaging a breast including the steps of: acquiring a two-dimensional image of a breast using a first x-ray dose, acquiring a three-dimensional image of the breast using a second x-ray dose less than the first x-ray dose and using the two-dimensional image and three-dimensional image to identify calcifications and masses in the breast, wherein acquisition of the two-dimensional image is separate from acquisition of the three-dimensional image.

10. A method of imaging a breast in a breast imaging system capable of generating two-dimensional images and three-dimensional images, including the steps of:

in response to an input selecting acquisition of a three-dimensional image, acquiring the three-dimensional image including the step of controlling an x-ray dosage administered during the acquisition of the three-dimensional image so that the x-ray dosage is less than a dosage used to acquire a two-dimensional image, wherein acquisition of the two-dimensional image is separate from acquisition of the three-dimensional image.

11. The method of step 12 wherein the step of controlling adjusts at least one of an x-ray voltage, x-ray current and x-ray filter.

12. The method of step 12 wherein the step of controlling adjusts at least one of an angle of a tomosynthesis scan and a number of projection images of the tomosynthesis scan.

Assignments (5)
CORRECTIVE ASSIGNMENT TO CORRECT THE INCORRECT PATENT NO. 8081301 PREVIOUSLY RECORDED AT REEL: 028810 FRAME: 0745. ASSIGNOR(S) HEREBY CONFIRMS THE SECURITY AGREEMENT. Recorded Nov 9, 2017
From: HOLOGIC, INC.; BIOLUCENT, LLC; CYTYC CORPORATION; CYTYC SURGICAL PRODUCTS, LIMITED PARTNERSHIP; SUROS SURGICAL SYSTEMS, INC.; THIRD WAVE TECHNOLOGIES, INC.; GEN-PROBE INCORPORATED
To: GOLDMAN SACHS BANK USA
Reel/Frame 044432/0565 →
CORRECTIVE ASSIGNMENT TO CORRECT THE INCORRECT PATENT NO. 8081301 PREVIOUSLY RECORDED AT REEL: 035820 FRAME: 0239. ASSIGNOR(S) HEREBY CONFIRMS THE SECURITY INTEREST RELEASE. Recorded Nov 9, 2017
From: GOLDMAN SACHS BANK USA, AS COLLATERAL AGENT
To: HOLOGIC, INC.; BIOLUCENT, LLC; CYTYC CORPORATION; CYTYC SURGICAL PRODUCTS, LIMITED PARTNERSHIP; SUROS SURGICAL SYSTEMS, INC.; THIRD WAVE TECHNOLOGIES, INC.; GEN-PROBE INCORPORATED
Reel/Frame 044727/0529 →
SECURITY AGREEMENT Recorded Aug 7, 2015
From: HOLOGIC, INC.; BIOLUCENT, LLC; CYTYC CORPORATION; CYTYC SURGICAL PRODUCTS, LIMITED PARTNERSHIP; DIRECT RADIOGRAPHY CORP.; GEN-PROBE INCORPORATED; GEN-PROBE PRODESSE, INC.; SUROS SURGICAL SYSTEMS, INC.; THIRD WAVE TECHNOLOGIES, INC.
To: BANK OF AMERICA, N.A., AS COLLATERAL AGENT
Reel/Frame 036307/0199 →
SECURITY INTEREST RELEASE REEL/FRAME 028810/0745 Recorded Jun 4, 2015
From: GOLDMAN SACHS BANK USA, AS COLLATERAL AGENT
To: HOLOGIC, INC.; BIOLUCENT, LLC; CYTYC CORPORATION; CYTYC SURGICAL PRODUCTS, LIMITED PARTNERSHIP; SUROS SURGICAL SYSTEMS, INC.; THIRD WAVE TECHNOLOGIES, INC.; GEN-PROBE INCORPORATED
Reel/Frame 035820/0239 →
SECURITY AGREEMENT Recorded Aug 1, 2012
From: HOLOGIC, INC.; BIOLUCENT, LLC; CYTYC CORPORATION; CYTYC SURGICAL PRODUCTS, LIMITED PARTNERSHIP; SUROS SURGICAL SYSTEMS, INC.; THIRD WAVE TECHNOLOGIES, INC.; GEN-PROBE INCORPORATED
To: GOLDMAN SACHS BANK USA
Reel/Frame 028810/0745 →