Metalloproteinase-12 specific monoclonal antibody
View Patent ↗Proteins that bind to matrix metalloproteinase 12 and methods of using such proteins are described.
1. An isolated Matrix Metalloproteinase-12 (MMP-12) specific monoclonal antibody, wherein the monoclonal antibody binds an epitope bound by an antibody having a heavy chain (HC) immunoglobulin variable domain sequence of SEQ ID NO. 1825 and a light chain (LC) immunoglobulin variable domain sequence of SEQ ID NO: 608.
2. The monoclonal antibody of claim 1 , wherein the monoclonal antibody binds human MMP-12.
3. The monoclonal antibody of claim 1 , wherein the monoclonal antibody inhibits the catalytic activity of MMP-12.
4. The monoclonal antibody of claim 1 , wherein the monoclonal antibody guides a nano-particle or toxin to a cell expressing MMP-12 on the cell surface.
5. The monoclonal antibody of claim 1 , wherein
the HC immunoglobulin variable domain sequence comprises a CDR1, CDR2 and CDR3 having the amino acid sequence of SEQ ID NO: 14, SEQ ID No. 936, and SEQ ID NO: 995, respectively; and
the LC immunoglobulin variable domain sequence comprises a CDR1, CDR2 and CDR3 having the amino acid sequence of SEQ ID NO: 84, SEQ ID NO: 152, and SEQ ID NO: 220, respectively.
6. The monoclonal antibody of claim 1 , wherein the monoclonal antibody comprises the light and heavy chains of SEQ ID NO:608 and SEQ ID NO: 1825, respectively.
7. A pharmaceutical composition comprising an MMP-12 specific monoclonal antibody of claim 1 and a pharmaceutically acceptable carrier.
8. The monoclonal antibody of claim 5 , wherein the monoclonal antibody comprises the light chain of SEQ ID NO: 608.
9. The monoclonal antibody of claim 5 , wherein the monoclonal antibody comprises the light chain of SEQ ID NO: 1825.