Methods for treating ocular inflammatory diseases
View Patent ↗A method of treating blepharitis includes administering to the affected eye of a subject an effective amount of an active ingredient in an ophthalmically acceptable vehicle for a sufficient period of time to treat blepharitis. The active ingredient consists essentially of a glucocorticoid in an ophthalmically acceptable vehicle that includes an aqueous polymer suspension that when mixed with tear fluid provides a sustained release of said active ingredient. The aqueous polymer suspension includes a carboxyl-containing polymer having less than about 5% by weight cross-linking agent and has a viscosity in a range from about 1,000 to about 30,000 centipoises. A kit includes: (a) a composition comprising about 0.1% by weight dexamethasone in this ophthalmically acceptable vehicle and (b) instructions for using the composition of (a) for the treatment of blepharitis.
1. A method of treating blepharitis having as its pathophysiological origin bacteria, the method comprising administering twice daily to the affected eye of a subject who has said blepharitis, for 14 days or more, a composition comprising an active ingredient consisting of about 0.1% by weight dexamethasone in an ophthalmically acceptable vehicle,
wherein the ophthalmically acceptable vehicle comprises an aqueous polymer suspension comprising a carboxyl-containing polymer having less than about 5% by weight cross-linking agent and an initial viscosity in a range from about 1,000 to about 30,000 centipoises, and which gels on contact with tear fluid,
wherein the method does not comprise administration of an antibiotic.
2. The method of claim 1 , wherein the carboxyl-containing polymer is polycarbophil.
3. The method of claim 2 , wherein the ophthalmically acceptable vehicle comprises 0.9% by weight of polycarbophil, 0.2% by weight of Polaxamer 407, an osmolality adjusting agent, a buffer in an amount sufficient to adjust a pH of the ophthalmically acceptable vehicle to be in a range from 3 to 6.5, and a preservative.