IP Library › Granted Patent US 8,158,616
Granted Patent B2
US 8,158,616 · App. 12/401,348 · Granted Apr 17, 2012

Azetidine and cyclobutane derivatives as JAK inhibitors

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Quick Facts
Patent No.
US 8,158,616
App. No.
12/401,348
Granted
Apr 17, 2012
Kind
B2
Abstract

The present invention relates to azetidine and cyclobutane derivatives, as well as their compositions, methods of use, and processes for preparation, which are JAK inhibitors useful in the treatment of JAK-associated diseases including, for example, inflammatory and autoimmune disorders, as well as cancer.

Claims (3)

1. {1-(Ethylsulfonyl)-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]azetidin-3-yl}acetonitrile, or a pharmaceutically acceptable salt thereof.

2. The compound of claim 1 wherein it is {1-(ethylsulfonyl)-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]azetidin -3-yl}acetonitrile phosphoric acid salt.

3. A composition comprising a compound of any one of claims 1 or 2 and at least one pharmaceutically acceptable carrier.

Assignments (3)
CORRECTIVE ASSIGNMENT TO CORRECT THE OMMISSION OF SECOND RECEIVING PARTY NAME PREVIOUSLY RECORDED AT REEL: 035292 FRAME: 0004. ASSIGNOR(S) HEREBY CONFIRMS THE ASSIGNMENT. Recorded Jul 2, 2015
From: INCYTE CORPORATION
To: INCYTE HOLDINGS CORPORATION; INCYTE CORPORATION
Reel/Frame 036054/0696 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 16, 2015
From: INCYTE CORPORATION
To: INCYTE HOLDINGS CORPORATION AND INCYTE CORPORATION
Reel/Frame 035924/0004 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 4, 2009
From: RODGERS, JAMES D.; SHEPARD, STACEY; LI, YUN-LONG; ZHOU, JIACHENG; LIU, PINGLI; MELONI, DAVID; XIA, MICHAEL
To: INCYTE CORPORATION
Reel/Frame 022637/0533 →