Sensor and sensing utilizing a laser
View Patent ↗Embodiments are generally described that include lasers having two mirrors, at least one of which has a reflectivity related to a presence or concentration of a target analyte. Output radiation generated by the laser may be related to the presence of the target analyte.
1. A sensor configured to receive energy from an excitation source, the sensor comprising:
a first mirror, the first mirror having a reflectivity related to a presence of a target analyte;
a second mirror; and
a gain medium between the first and second mirrors, the gain medium configured to amplify the energy received from the excitation source wherein the cooperative operation of the first mirror, the second mirror and the gain medium is arranged to generate output radiation in response to the energy received from the excitation source, the output radiation related to the presence of the target analyte; and
a detector positioned to receive the output radiation transmitted through the second mirror.
2. The sensor according to claim 1 wherein the first mirror comprises a first mirror material having a first surface and a coating on the first surface, the coating suitable to bind with the target analyte.
3. The sensor according to claim 1 wherein the coating comprises an antibody.
4. The sensor according to claim 1 wherein the laser is configured to generate an amount of output radiation based in part on the presence of the target analyte.
5. The sensor according to claim 1 wherein the first mirror includes a material whose reflectivity is related to the presence of the target analyte.
6. The sensor according to claim 1 wherein the detector is configured to monitor the output radiation generated by the sensor, detect a change in the output radiation generated by the laser and indicate the presence of the target analyte based on the change.
7. The sensor according to claim 1 wherein the detector is configured to compare the output radiation with a calibration value and indicate the presence of the target analyte based in part on the comparison.
8. The sensor according to claim 1 further comprising a calibration laser, the calibration laser configured to generate calibration output radiation substantially unrelated the presence of the target analyte, the detector configured to compare the output radiation with the calibration output radiation and indicate the presence of the target analyte based in part on the comparison.
9. The sensor according to claim 1 wherein the laser comprises a vertical-cavity surface-emitting laser coupled to a substrate with at least one flip-chip bump, and wherein the excitation source and the detector are supported by the substrate.
10. The sensor according to claim 9 wherein the detector comprises a photodiode formed in the substrate.
11. A sensor system comprising:
a substrate;
an array of lasers supported by the substrate, each laser comprising:
a first mirror, the first mirror having a reflectivity related to a presence or concentration of a respective target analyte;
a second mirror; and
a gain medium between the first and second mirrors;
an excitation source coupled to at least one of the lasers of the array, the excitation source configured to excite the respective laser to generate output radiation, an amount of output radiation based in part on the presence or concentration of the respective target analyte; and
a detector coupled to at least one of the lasers, wherein the detector is configured to receive the output radiation transmitted through the second mirror and also configured to generate a detection signal based on the output radiation.
12. The sensor according to claim 11 wherein each of the lasers is sensitive to a presence of a different target analyte.
13. The sensor according to claim 11 wherein the array of lasers comprises an array of vertical-cavity surface-emitting lasers.
14. The sensor according to claim 13 wherein the first mirror of each of the respective lasers is coated with a different antibody configured to bind to the respective target analyte.
15. A method for detecting a target analyte, the method comprising:
exciting a laser to produce an amount of output radiation related to a presence or concentration of the target analyte, wherein the laser includes a gain medium between a first mirror having a reflectivity related to a presence of a target analyte and a second mirror;
detecting the amount of output radiation transmitted through the second mirror; and
indicating the presence or concentration of the target analyte based on the amount of output radiation.
16. The method according to claim 15 wherein the act of indicating the presence of the target analyte comprises comparing the amount of output radiation with a calibration amount.
17. The method according to claim 16 further comprising exciting a calibration laser to produce the calibration amount of output radiation.
18. The method according to claim 15 wherein the act of indicating the presence of the target analyte comprises transmitting the indication over a wireless communication network.
19. The method according to claim 15 wherein the method further comprises exciting a plurality of lasers to produce respective amounts of output radiation, each respective amount of output radiation related to a presence of a respective target analyte;
detecting the respective amounts of output radiation; and
indicating the presence of one or more target analytes based on the respective amount of output radiation.