Methods for treating bone cancer pain by administering a nerve growth factor antagonist antibody
The invention features methods and compositions for preventing or treating bone cancer pain including cancer pain associated with bone metastasis by administering an antagonist of nerve growth factor (NGF). The NGF antagonist may be an anti-NGF (such as anti-hNGF) antibody that is capable of binding hNGF.
1. A method for treating bone cancer pain in an individual comprising administering to the individual an effective amount of a anti-nerve growth factor (NGF) antagonist antibody, wherein the anti-NGF antagonist antibody comprises the amino acid sequence shown in SEQ ID NO:1.
2. The method of claim 1 , wherein the anti-NGF antagonist antibody further comprises the amino acid sequence shown in SEQ ID NO:2.
3. The method of claim 2 , wherein the anti-NGF antagonist antibody binds human NGF.
4. The method of claim 2 , wherein the bone cancer pain is from cancer originated in bone.
5. The method of claim 2 , wherein the bone cancer pain is from osteosarcoma.
6. The method of claim 2 , wherein the bone cancer pain is from cancer metastasized to bone.
7. The method of claim 6 , wherein the bone cancer pain is from prostate cancer metastasized to bone.
8. The method of claim 6 , wherein the bone cancer pain is from breast cancer metastasized to bone.
9. The method of claim 6 , wherein the bone cancer pain is from lung cancer metastasized to bone.
10. The method of claim 6 , wherein the bone cancer pain is from sarcoma metastasized to bone.
11. The method of claim 6 , wherein the bone cancer pain is from renal cancer metastasized to bone.
12. A method for treating bone cancer pain in an individual comprising administering to the individual an effective amount of a anti-nerve growth factor (NGF) antagonist antibody, wherein the anti-NGF antagonist antibody comprises the amino acid sequence shown in SEQ ID NO:2.