DEVICES AND METHODS FOR THE ENDOLUMENAL TREATMENT OF OBESITY
Devices and methods for forming and securing tissue folds and elongated invaginations in stomach tissue are used as a treatment for obesity. In a first embodiment, a plurality of tissue folds is formed in the fundus region of the stomach. In a second embodiment, one or more elongated invaginations is formed in the body region of the stomach. In a third embodiment, a plurality of tissue folds is formed in the fundus region of the stomach and one or more elongated invaginations is formed in the body region of the stomach. Additional embodiments include various combinations of tissue folds, elongated invaginations, and other reconfigurations of stomach tissue.
1 . An endolumenal treatment method, comprising:
advancing a delivery catheter through a patient's mouth and esophagus and into the patient's stomach, the delivery catheter including a flexible tube having a needle at its distal end, with a first tissue anchor assembly being contained within the flexible tube of the delivery catheter;
forming a first tissue fold in the tissue of the stomach fundus, the tissue fold including a serosa-to-serosa contact of tissue on the peritoneal surface of the stomach fundus;
passing the needle of the delivery catheter through the first tissue fold;
deploying the first tissue anchor assembly from the delivery catheter through the first tissue fold to thereby secure the first tissue fold;
securing a first plurality of additional tissue folds in the tissue of the stomach fundus;
forming a first elongated invagination of tissue in the body region of the stomach extending generally from the fundus toward the antrum, the first elongated invagination including a serosa-to-serosa contact of tissue on the peritoneal surface of the stomach body region; and
deploying a plurality of tissue anchor assemblies from the delivery catheter through the first elongated invagination of tissue to thereby secure the tissue.
2 . The endolumenal treatment method of claim 1 , wherein the first elongated invagination is located substantially on the anterior wall of the stomach body region.
3 . The endolumenal treatment method of claim 1 , wherein the first elongated invagination is located substantially on the lateral wall of the stomach body region.
4 . The endolumenal treatment method of claim 1 , further comprising the step of deploying a plurality of tissue anchor assemblies from the delivery catheter through a second elongated invagination of tissue formed in the body region of the stomach.
5 . The endolumenal treatment method of claim 1 , wherein the first elongated invagination has a length of from about 0.5 cm to about 30 cm.
6 . The endolumenal treatment method of claim 1 , further comprising the step of viewing the securing and deploying steps through an endoscope extending through a lumen of the delivery catheter.
7 . The endolumenal treatment method of claim 1 , further comprising the step of securing a second plurality of additional tissue folds in the tissue of the stomach body region.
8 . The endolumenal treatment method of claim 7 , wherein said second plurality of additional tissue folds are substantially aligned in one or more rows extending longitudinally from the fundus toward the antrum.
9 . The endolumenal treatment method of claim 1 , wherein the first elongated invagination comprises a substantially continuous line of contact of serosal tissue on the peritoneal surface of the stomach extending substantially from the fundus to the antrum.
10 . The endolumenal treatment method of claim 4 , wherein the first elongated invagination and second elongated invagination each comprise a substantially continuous line of contact of serosal tissue on the peritoneal surface of the stomach extending substantially from the fundus to the antrum.