Medical device for assessing intravascular blood volume and technique for using the same
Embodiments of the present invention relate to a system and method for determining a physiologic parameter of a patient. Specifically, embodiments of the present invention include methods and systems for correcting a pulse oximetry plethysmographic waveform variability measurement based on parameters that may influence the waveform variability. The corrected measurement may be used to estimate intravascular blood volume and/or fluid responsiveness of a patient.
1. A method, comprising:
using a processor:
receiving a plethysmographic waveform signal from a sensor, wherein the plethysmographic waveform signal is representative of a blood oxygen saturation of a patient;
receiving information related to a patient parameter that influences the plethysmographic waveform signal; and
determining a plethysmographic waveform variability based at least in part on the plethysmographic waveform signal; and
correcting the plethysmographic waveform variability to generate a corrected variability value based on the information related to the patient parameter, wherein the information related to the patient parameter comprises a tissue carbon dioxide level.
2. The method of claim 1 , comprising providing an indication of intravascular blood volume based on the corrected variability value.
3. The method of claim 1 , comprising triggering an alarm when the corrected variability value is greater than a predetermined level or outside of a predetermined range.
4. The method of claim 3 , wherein the predetermined level is 15%.
5. The method of claim 1 , wherein the information related to the patient parameter comprises a ventilator setting of positive end pressure ventilation, a tidal volume, a respiration rate, an end-tidal carbon dioxide level, or any combination thereof.
6. The method of claim 1 , wherein the information related to the patient parameter comprises a clinical condition of the patient or information related to a pharmacological treatment.
7. The method of claim 6 , wherein the clinical condition comprises a likelihood of vasoconstriction.
8. A monitor, comprising:
an input circuit configured to receive a plethysmographic waveform signal and information relating to a patient parameter that influences the plethysmographic waveform signal;
a memory storing an algorithm configured to calculate a corrected plethysmographic waveform variability based at least in part on the plethysmographic waveform signal and the information related to the patient parameter wherein the information relating to the patient parameter comprises information that the patient is undergoing positive end expiratory pressure ventilation, and wherein the algorithm is configured to increase the plethysmographic waveform variability based on the information; and
an output circuit configured to provide an indication of the corrected plethysmographic waveform variability.
9. The monitor of claim 8 , wherein the information relating to a patient parameter comprises information received from a carbon dioxide sensor or a tissue water fraction sensor.
10. The monitor of claim 8 , wherein the information relating to a patient parameter comprises respiratory parameter information.
11. The monitor of claim 8 , wherein the algorithm comprises the following equation:
W v =( W max −W min )/ W mean ,
wherein W v is the plethysmographic waveform variability, W max is a maximum peak value for a largest peak, W min is a minimum peak value for a smallest peak, and W mean represents the mean vertical distance between peak maxima and minima for the consecutive peaks in the window within a window of consecutive peaks.
12. The monitor of claim 8 , wherein the information related to the patient parameter comprises a tidal volume, and wherein the algorithm is configured to correct the plethysmographic waveform variability when the tidal volume is outside of a range of between 8 to 15 kg/ml.
13. The monitor of claim 8 , wherein the information relating to the patient parameter comprises information that the patient is receiving vasoconstrictive drugs, and wherein the algorithm is configured to adjust the plethysmographic waveform variability based on the information.
14. A method, comprising:
using a processor:
receiving a plethysmographic waveform signal from a sensor, wherein the plethysmographic waveform signal is representative of a blood oxygen saturation of a patient;
receiving information related to a patient parameter that influences the plethysmographic waveform signal; and
determining a plethysmographic waveform variability based at least in part on the plethysmographic waveform signal; and
correcting the plethysmographic waveform variability to generate a corrected variability value based on the information related to the patient parameter, wherein the information related to the patient parameter comprises a tissue water fraction.
15. The method of claim 14 , comprising providing an indication of intravascular blood volume based on the corrected variability value.
16. The method of claim 14 , comprising triggering an alarm when the corrected variability value is greater than a predetermined level or outside of a predetermined range.
17. The method of claim 16 , wherein the predetermined level is 15%.
18. The method of claim 14 , wherein the information related to the patient parameter comprises a ventilator setting of positive end pressure ventilation, a tidal volume, a respiration rate, an end-tidal carbon dioxide level, or any combination thereof.