Delivery of antipsychotics through an inhalation route
View Patent ↗The present invention relates to the delivery of antipsychotics through an inhalation route. Specifically, it relates to aerosols containing antipsychotics that are used in inhalation therapy. In a method aspect of the present invention, an antipsychotic is delivered to a patient through an inhalation route. The method comprises: a) heating a composition, wherein the composition comprises an antipsychotic, to form a vapor; and, b) allowing the vapor to cool, thereby forming a condensation aerosol comprising particles with less than 5% antipsychotic drug degradation products. In a kit aspect of the present invention, a kit for delivering an antipsychotic through an inhalation route is provided which comprises: a) a thin coating of an antipsychotic composition and b) a device for dispensing said thin coating as a condensation aerosol.
1. An aerosol for delivery of loxapine by inhalation comprising condensation particles having an MMAD of 0.2 to 5 microns and a high particle concentration of the condensation particles.
2. The aerosol of claim 1 , wherein the aerosol is at least 90% free of additional compounds.
3. The aerosol of claim 1 , wherein the condensation particles have and MMAD of 1-3 microns.
4. The aerosol of claim 1 , wherein the high particle concentration of the condensation particles is about 10 9 particles/ml.
5. An aerosol for delivery of loxapine by inhalation comprising condensation particles having an MMAD of 0.2 to 5 microns and a particle density greater than 10 6 particles/ml.
6. The aerosol of claim 5 , wherein the aerosol is at least 90% free of additional compounds.
7. The aerosol of claim 5 , wherein the condensation particles have an MMAD of 1-3 microns.
8. The aerosol of claim 5 , wherein the aerosol has a particle density of about 10 9 particles/ml.