Freeze-dryer and method of controlling the same
View Patent ↗A freeze-dryer and method of controlling the same is provided. The disclosed freeze-dryer includes a chamber adapted to hold material or product to be freeze-dried; one or more depressurization orifices; a gas pressurization circuit having a source of gas to pressurize the chamber to a prescribed pressure; a depressurization circuit coupled to the chamber via the one or more orifices and having a depressurizing control valve; and a control unit adapted to pressurize the chamber with the source of gas and actuate the depressurizing control valve to depressurize the chamber upon command. The ratio of total depressurization orifice area to the chamber volume is preferably between about 6×10 −2 and about 4×10 −4 m 2 /m 3 .
1. A freeze-dryer system comprising:
a freeze-drying chamber defining a freeze-drying chamber volume;
one or more depressurization orifices in fluid communication with the freeze-drying chamber;
a gas pressurization circuit having a source of gas coupled to the freeze-dryer to pressurize the freeze-drying chamber to a prescribed pressure;
a depressurization circuit coupled to the freeze-drying chamber via the one or more depressurization orifices, the depressurization circuit further including one or more depressurization control valves that together with the one or more depressurization orifices defines a total depressurization orifice area; and
a micro-processor based control unit adapted to pressurize the freeze-drying chamber with the source of gas upon receipt of a pressurization command input or actuate the depressurization control valve to rapidly depressurize the freeze-drying chamber upon receipt of a depressurization command input
wherein the ratio of total depressurization orifice area to the freeze-drying chamber volume is between about 1×10 −1 and about 1×10 −4 m 2 /m 3 .
2. The freeze-dryer system of claim 1 wherein the depressurization circuit further comprises one or more valves operatively controlled to allow adjustments or variations to the total depressurization orifice area.
3. The freeze-dryer system of claim 1 wherein the depressurization circuit further comprises one or more valves operatively controlled to allow adjustments or variations to the total depressurization time.
4. The freeze-dryer system of claim 1 wherein the gas pressurization circuit further comprises:
a source of gas;
a gas regulator coupled to the source of gas to control the delivery pressure and flow rate of the gas;
a gas filter disposed downstream of the source of gas; and
a pressurization control valve operatively associated with the micro-processor based control unit, the pressurization control valve interposed between the source of gas and the freeze-drying chamber;
wherein the pressurization control valve is maintained in a first position during pressurization of the freeze-drying chamber to the prescribed pressure using the gas and a second position during depressurization of the freeze-drying chamber.
5. The freeze-dryer system of claim 1 wherein the source of gas is an inert gas.
6. The freeze-dryer system of claim 1 wherein the ratio of total depressurization orifice area to the freeze-drying chamber volume is between about 6×10 −2 and about 4×10 −4 m 2 /m 3 .
7. The freeze-dryer system of claim 1 further comprising one or more temperature sensors disposed in the freeze-drying chamber and operatively connected to the control unit and wherein the depressurization command input is generated when the temperature sensors detect a prescribed temperature.
8. The freeze-dryer system of claim 7 wherein the depressurization command input is generated a prescribed time after the temperature sensors detect the prescribed temperature.