Self cleaning devices, systems and methods of use
View Patent ↗The invention relates to medical devices, systems and methods for preventing the embolic material flowing about a junction of at least one branch blood vessel and another blood vessel from entering the other blood vessel. The device includes a self cleaning flexible filter and a frame. The external surface of the filter is configured to temporarily trap at least some of the embolic material flowing about the junction as a result of the blood inflow though the filter. The filter is also configured to expel the trapped embolic material into the other blood vessel.
1. A self cleaning device, comprising:
a first flexible filter comprising tapered pores and having a first end, a second end, and a first external surface, the first end configured to reside at or near a junction of at least one branch blood vessel and another blood vessel, and the second end configured to extend at least partially within the other blood vessel; and
a first frame positioned at least at the first end of the first filter and configured to hold the first end of the first filter at the junction of the at least one branch blood vessel and the other blood vessel;
where the first external surface of the first filter has a first configuration adapted to temporarily trap at least some of the embolic material flowing about the junction of the at least one branch blood vessel and the other blood vessel as a result of blood inflow through the first filter, and a second configuration adapted to expel the trapped embolic material into the other blood vessel.
2. The device of claim 1 , wherein the pores range in size from about 0.02 mm to about 0.5 mm.
3. The device of claim 2 , wherein the pores form a taper or a cylindrical hole as a result of the first flexible filter release force.
4. The device of claim 2 , wherein the first filter comprises a material selected from the group consisting of polytetrafluoroethylene, polyurethane, and silicone rubbers.
5. The device of claim 1 , wherein the first filter comprises pleats.
6. The device of claim 1 , further comprising at least one supporting wire, the supporting wire comprising two support elements and at least one loop.
7. The device of claim 6 , wherein the support elements comprise nitinol.
8. The device of claim 1 , wherein the first filter, the first frame, or both comprise at least one agent to enhance endothelialization or to prevent the growth of smooth muscle or certain other tissues on any surface of the first filter, the first frame, or both.
9. The device of claim 8 , wherein the agent is selected from the group consisting of endothelial cells derived from the subject prior to installation of the device in the subject, a nitric oxide emitter compound, an antibody to circulating progenitor cells, at least one fibronectin-derived low-molecular-weight peptide fragment, Resten-NG, AVI-4126, and AVI-5126.
10. The device of claim 1 , wherein the at least one branch blood vessel is the brachiocephalic artery and the other blood vessel is the aorta.
11. The device of claim 1 , further comprising a tubular member configured to hold at least the first filter.
12. The device of claim 11 , wherein the tubular member is a stent.
13. The device of claim 1 , wherein the first flexible filter has an open area of at least 50%.
14. The device of claim 1 , wherein the first flexible filter is configured to be replaced.
15. The device of claim 1 , wherein the device is configured for permanent implantation into a subject.
16. The device of claim 1 , further comprising
a second flexible filter, the second filter having a first end, a second end, a second external surface, and a second release force, the first end of the second filter configured to reside at or near a junction of the at least one branch blood vessel and the other blood vessel, and the second end of the second filter configured to extend at least partially within the other blood vessel; and
a second frame positioned at least at the first end of the second filter and configured to hold the first end of the second filter at the junction of the at least one branch blood vessel and the other blood vessel;
wherein the second external surface of the second filter is configured to temporarily trap at least some of the embolic material flowing about the junction of the at least one branch blood vessel and the other blood vessel as a result of blood inflow though the second filter, and wherein the second external surface of the filter is further configured to expel the trapped embolic material into the other blood vessel as a result of a second filter release force.
17. The device of claim 16 , wherein the at least one branch blood vessel includes the brachiocephalic artery and left common carotid artery, and the other blood vessel is the aorta.
18. The device of claim 16 , further comprising a tubular member configured to hold at least the first filter and the second filter.
19. A method for preventing embolic stroke in a subject, the method comprising placing the device of claim 1 at the junction of the at least one branch blood vessel and the other blood vessel.
20. A method for preventing embolic stroke in a subject, the method comprising placing the device of claim 16 at the junction of the at least one branch blood vessel and the other blood vessel.