IP Library › Patent Application 12420390
Patent Application
App. No. 12/420,390

METHOD OF TREATING OF DEMYELINATING DISEASES OR CONDITIONS

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Quick Facts
Patent No.
US None
App. No.
12/420,390
Abstract

N-(Pyridinyl)-1H-indol-1-amines of formula I provide a unique combination of blocking properties for both the potassium and sodium channels. These compounds are useful for the treatment of Demyelinating Diseases and Conditions such as Multiple Sclerosis, Spinal Cord Injury, Traumatic Brain Injury and Stroke. The compounds are also useful for Stroke Rehabilitation, the treatment of Bladder Irritation and Dysfunction, and the treatment of Neuropathic Pain and Chemokine-Induced Pain.

Claims (3)

1 . A method for treating multiple sclerosis, in a patient in need thereof, comprising administering to the patient a therapeutically effective amount of a compound of formula

or a pharmaceutically acceptable salt thereof.

2 . The method according to claim 1 , wherein the pharmaceutically acceptable salt is hydrochloride salt.

Assignments (3)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 25, 2009
From: SMITH, CRAIG P.; PETTY, MARGARET; RAMPE, DAVID
To: AVENTIS PHARMACEUTICALS INC.
Reel/Frame 023281/0977 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 25, 2009
From: RATHBONE, MICHEL P.
To: MCMASTER UNIVERSITY
Reel/Frame 023283/0001 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 25, 2009
From: MCMASTER UNIVERSITY
To: AVENTIS PHARMACEUTICALS INC.
Reel/Frame 023283/0038 →