Method for stabilizing retinoic acid, retinoic acid containing composition, and method of using a retinoic acid containing composition
View Patent ↗A method for stabilizing retinoic acid is provided. The method includes a step of mixing retinoic acid with a hydrophobic polymer/hydrophilic polymer adduct in the presence of an oxygen containing atmosphere to form a retinoic acid containing composition. The hydrophobic polymer/hydrophilic polymer adduct comprises a poly(vinylpyrrolidone/alkylene) polymer and a polymer comprising repeating carboxylic acid groups, hydroxyl groups, or a mixture of carboxylic acid groups and hydroxyl groups. A retinoic acid containing composition and a method of using a retinoic acid containing composition are provided.
1. A method for stabilizing retinoic acid, the method comprising:
mixing retinoic acid with a hydrophobic polymer/hydrophilic polymer adduct comprising a poly(vinylpyrrolidone-alkylene) polymer and cellulose to form a retinoic acid containing composition comprising about 0.01 wt. % to about 0.15 wt. % of the retinoic acid, wherein the step of mixing comprises mixing in the presence of an oxygen containing atmosphere, wherein the retinoic acid containing composition retains at least about 70% of its original activity after accelerated testing at 40° C. for 120 days with exposure to an oxygen atmosphere.
2. A method according to claim 1 , wherein the poly(vinylpyrrolidone-alkylene) polymer comprises a polymer having an alkylene group containing about 10 carbon atoms to about 30 carbon atoms.
3. A method according to claim 1 , wherein the composition comprises at least about 50 wt. % water.
4. A method according to claim 1 , wherein the composition comprises about 0.5 wt. % to about 6 wt. % of a surfactant.
5. A method according to claim 1 , wherein the composition comprises about 0.1 wt. % to about 2 wt. % of a thickener.
6. A method according to claim 1 , wherein the composition comprises about 0.5 wt. % to about 5 wt. % of a moisturizer.
7. A method according to claim 1 , wherein the cellulose has a weight average molecular of about 50,000 to about 15,000,000.
8. A method according to claim 1 , wherein the cellulose comprises cellulose gum.
9. A method according to claim 1 , wherein the cellulose comprises carboxymethyl cellulose.
10. A method according to claim 1 , wherein the hydrophobic polymer/hydrophilic polymer adduct comprises about 2 wt. % to about 28 wt. % of the hydrophilic polymer and about 72 wt. % to about 98 wt. % of the hydrophobic polymer.
11. A method according to claim 1 , wherein the retinoic acid containing composition comprises about 3 wt. % to about 20 wt. % of the hydrophobic/hydrophilic polymer adduct.
12. A method according to claim 1 , wherein the retinoic acid containing composition comprises about 4 wt. % to about 15 wt. % of the hydrophobic/hydrophilic polymer adduct.
13. A retinoic acid containing composition comprising:
(a) at least about 0.0001 wt. % retinoic acid;
(b) at least about 3 wt. % of a hydrophobic polymer/hydrophilic polymer adduct comprising a poly(vinylpyrrolidone-alkylene) polymer and cellulose;
(c) at least about 50 wt. % water;
(d) wherein the retinoic acid containing composition retains at least about 70% of its original activity after accelerated testing at 40° C. for 120 days with exposure to an oxygen atmosphere, and
(e) wherein the composition is made by mixing the polyvinylpyrrolidone-alkylene) polymer, cellulose, and retinoic acid in the presence of an oxygen containing atmosphere.
14. A retinoic acid containing composition according to claim 13 wherein the poly(vinylpyrrolidone-alkylene) polymer comprises a polymer having an alkylene group containing about 10 carbon atoms to about 30 carbon atoms.
15. A retinoic acid containing composition according to claim 13 , wherein the composition comprises about 0.5 wt. % to about 6 wt. % of a surfactant.
16. A retinoic acid containing composition according to claim 13 , wherein the composition comprises about 0.1 wt. % to about 2 wt. % of a thickener.
17. A retinoic acid containing composition according to claim 13 , wherein the composition comprises about 0.5 wt. % to about 5 wt. % of a moisturizer.
18. A retinoic acid containing composition according to claim 13 , wherein the composition comprises about 0.01 wt. % to about 0.15 wt. % of retinoic acid.
19. A retinoic acid containing composition according to claim 13 , wherein the cellulose has a weight average molecular of about 50,000 to about 15,000,000.
20. A retinoic acid containing composition according to claim 13 , wherein the cellulose comprises cellulose gum.
21. A retinoic acid containing composition according to claim 13 , wherein the cellulose comprises carboxymethyl cellulose.
22. A retinoic acid containing composition according to claim 13 , wherein the hydrophobic polymer/hydrophilic polymer adduct comprises about 2 wt. % to about 28 wt. % of the hydrophilic polymer and about 72 wt. % to about 98 wt. % of the hydrophobic polymer.
23. A retinoic acid containing composition according to claim 13 , wherein the retinoic acid containing composition comprises about 3 wt. % to about 20 wt. % of the hydrophobic/hydrophilic polymer adduct.
24. A retinoic acid containing composition according to claim 13 , wherein the retinoic acid containing composition comprises about 4 wt. % to about 15 wt. % of the hydrophobic/hydrophilic polymer adduct.