IP Library › Granted Patent US 7,989,465
Granted Patent B2
US 7,989,465 · App. 12/426,495 · Granted Aug 2, 2011

4,6-disubstituted pyrimidines useful as kinase inhibitors

Assignee: Avila Therapeutics, Inc.
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Quick Facts
Patent No.
US 7,989,465
App. No.
12/426,495
Granted
Aug 2, 2011
Kind
B2
Abstract

The present invention provides 4,6-disubstituted pyrimidine compounds useful as kinase inhibitors, pharmaceutically acceptable salts and compositions thereof, and methods of using the same. The present invention also provides probe compounds, such as compounds of formula V: wherein each of Ring A, Ring B, R 1′ , T, R t , m, R x , R y , and W is described herein.

Claims (5)

1. A compound selected from the group consisting of:

or a pharmaceutically acceptable salt thereof.

2. A composition comprising a compound according to claim 1 , and a pharmaceutically acceptable adjuvant, carrier, or vehicle.

3. A compound having one of the following structures:

4. A compound of the following structure:

Assignments (2)
CHANGE OF NAME Recorded Sep 28, 2012
From: AVILA THERAPEUTICS, INC.
To: CELGENE AVILOMICS RESEARCH, INC.
Reel/Frame 029058/0066 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 8, 2009
From: SINGH, JUSWINDER; GHOSH, SHOMIR; KLUGE, ARTHUR F.; PETTER, RUSSELL C.; TESTER, RICHLAND W.
To: AVILA THERAPEUTICS, INC.
Reel/Frame 023202/0405 →
Continuity (4)
Continuation In Part 12253424 · Oct 17, 2008
Provisional Application 60981432 · Oct 19, 2007
Provisional Application 61052002 · May 9, 2008
Related Publication 20100016296A1 · Jan 21, 2010