Benzene sulfonamide thiazole and oxazole compounds
View Patent ↗The present invention provides thiazole sulfonamide and oxazole sulfonamide compounds, compositions containing the same, as well as processes for the preparation and methods for their use as pharmaceutical agents.
1. A compound of formula
or a pharmaceutically acceptable salt thereof.
2. A pharmaceutical composition, comprising a compound of claim 1 , together with one or more of pharmaceutically acceptable carriers, diluents or excipients.
3. A pharmaceutical composition as claimed in claim 2 in unit dosage form.
4. A method of treatment of a human suffering from melanoma, which comprises administering to said subject an effective amount of a compound as claimed in claim 1 .
5. The method of claim 4 , wherein the melanoma is metastatic melanoma having a mutation encoding a V600E amino acid substitution.
6. A compound of formula
7. A pharmaceutical composition, comprising a compound of claim 6 , together with one or more of pharmaceutically acceptable carriers, diluents or excipients.
8. A pharmaceutical composition as claimed in claim 7 in unit dosage form.
9. A method of treatment of a human suffering from melanoma, which comprises administering to said subject an effective amount of a compound as claimed in claim 6 .
10. The method of claim 9 , wherein the melanoma is metastatic melanoma having a mutation encoding a V600E amino acid substitution.
11. A pharmaceutically acceptable salt of the compound of formula
12. A pharmaceutical composition, comprising a compound of claim 11 , together with one or more of pharmaceutically acceptable carriers, diluents or excipients.
13. A pharmaceutical composition as claimed in claim 12 in unit dosage form.
14. A method of treatment of a human suffering from melanoma, which comprises administering to said subject an effective amount of a compound as claimed in claim 11 .
15. The method of claim 14 , wherein the melanoma is metastatic melanoma having a mutation encoding a V600E amino acid substitution.
16. N-{3-[5-(2-amino-4-pyrimidinyl)-2-(1,1-dimethylethyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,6-difluorobenzenesulfonamide mesylate.
17. A pharmaceutical composition, comprising a compound of claim 16 , together with one or more of pharmaceutically acceptable carriers, diluents or excipients.
18. A pharmaceutical composition as claimed in claim 16 in unit dosage form.
19. A method of treatment of a human suffering from melanoma, which comprises administering to said subject an effective amount of a compound as claimed in claim 16 .
20. The method of claim 19 , wherein the melanoma is metastatic melanoma having a mutation encoding a V600E amino acid substitution.