IP Library › Granted Patent US 7,816,362
Granted Patent B2
US 7,816,362 · App. 12/435,862 · Granted Oct 19, 2010

Serotonergic agents

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Quick Facts
Patent No.
US 7,816,362
App. No.
12/435,862
Granted
Oct 19, 2010
Kind
B2
Abstract

Novel piperazine derivatives are provided having the formula wherein R 1 is cyano, nitro, trifluoromethyl or halogen, or pharmaceutically acceptable acid addition salts thereof, which are useful as 5-HT 1A receptor antagonists.

Claims (3)

1. A method for potentiating the effects of a serotonin reuptake inhibitor in a patient in need thereof, the method comprising providing to the patient a therapeutically effective amount of a compound of formula (III):

wherein R 1 is cyano, nitro, trifluoromethyl or halogen, or a pharmaceutically acceptable acid addition salt thereof.

2. The method of claim 1 , wherein the compound is (R)-4-cyano-N-{2-[4-(2,3-dihydro-benzo[1,4]dioxin-5-yl)piperazine-1-yl]-propyl}-N-pyridin-2-yl-benzamide.