UV-absorbers for ophthalmic lens materials
View Patent ↗UV absorbing monomers that are particularly useful in ophthalmic devices are disclosed.
1. An intraocular lens comprising the UV absorber of formula (I):
wherein
R 1 ═H, CH 3 , CH 3 CH 2 , (CH 3 ) 2 CH, CH 3 CH 2 CH 2 , HOCH 2 , CH 2 F, (CH 3 ) 3 C, (CH 3 ) 3 COCH 2 , HOC(O)CHOCH 3 , C(O)OH, CH 3 OC(O)CHNH 2 CH 2 , CH 3 CH 2 OC(O)(CH 2 ) 2 , (CH 3 O) 2 CH, (CH 3 ) 2 CHOC(O), CH 3 CH 2 OC(O), CH 3 OC(O), (CH 3 CH 2 O) 2 CH, CH 3 OC(O)(CH 2 ) 2 , CH 3 OC(O)CH 2 NHCH 2 , CH 3 CH 2 OC(O)CH 2 , C 6 H 5 , C 6 H 4 OH, C 6 H 5 CH 2 , C 6 H 4 CNCH 2 , C 6 H 4 NO 2 , C 6 H 4 NH 2 CH 2 , CH 2 CH 2 CHOC(O), CH 2 ═CHC(O)OCH 2 , CH 2 ═CCH 3 C(O)OCH 2 , CH 2 ═CHC(O)OCH 2 CH 2 NHC(O), CH 2 ═CCH 3 C(O)OCH 2 CH 2 NHC(O), CH 2 ═CHC(O)OCH 2 CH 2 NHC(O)OCH 2 , or CH 2 ═CCH 3 C(O)OCH 2 CH 2 NHC(O)OCH 2 ;
R 2 , R 3 , and R 4 independently=H, OH, CH 3 O, CH 3 CH 2 O, CH 3 CH 2 CH 2 O, (CH 3 ) 2 CHO, (CH 3 ) 3 CO, CH 3 C(O)O, C 6 H 5 CH 2 O, HOCH 2 CH 2 O, HOCH 2 CH 2 CH 2 O, CH 2 ═CHC(O)OCH 2 CH 2 O, CH 2 ═CCH 3 C(O)OCH 2 CH 2 ), CH 2 ═CCH 3 C(O)O, CH 2 ═CHC(O)O, CH 2 ═CHC(O)OCH 2 CH 2 NHC(O), CH 2 ═CCH 3 C(O)OCH 2 CH 2 NCH(O), CH 2 ═CHC(O)OCH 2 CH 2 NHC(O)OCH 2 CH 2 O, or CH 2 ═CCH 3 C(O)OCH 2 CH 2 NHC(O)OCH 2 CH 2 O; or R 2 ═H and R 3 and R 4 taken together form a methylenedioxy group; and
provided that at least one of R 1 , R 2 , R 3 , and R 4 must contain a methacrylate or acrylate moiety.
2. The intraocular lens of claim 1 comprising the UV absorber of formula (I) wherein R 1 ═H, CH 3 , HOCH 2 , CH 3 CH 2 OC(O), CH 2 ═CHC(O)OCH 2 , CH 2 ═CCH 3 C(O)OCH 2 , or CH 2 ═CHC(O)OCH 2 CH 2 NHC(O), CH 2 ═CCH 3 C(O)OCH 2 CH 2 NHC(O).
3. The intraocular lens of claim 1 comprising the UV absorber of formula (I) wherein R 2 , R 3 , and R 4 independently=H, OH, CH 3 O, CH 3 CH 2 O, CH 3 C(O)O, C 6 H 5 CH 2 O, CH 2 ═CHC(O)OCH 2 CH 2 O, or CH 2 ═CCH 3 C(O)OCH 2 CH 2 O; or R 2 ═H and R 3 and R 4 taken together form a methylenedioxy group; and provided that only one of R 1 , R 2 , R 3 , and R 4 contains a methacrylate or acrylate moiety.
4. An intraocular lens comprising 2-(2-methoxy-4-(2-nitroprop-1-enyl)phenoxy)ethyl methacrylate.