Solid tartrate salts of DPP-IV inhibitors
View Patent ↗This invention relates to DPP-IV inhibitory citrate or tartrate salts of pyrrolidinylaminoacetyl pyrrolidine boronic acid compounds that are physically and chemically stable, substantially non-deliquescent solids under ambient conditions.
1. A solid form of a tartrate salt hydrate of a pyrrolidine compound of formula
or a cyclic form thereof of formula
or a mixture thereof, wherein the solid form comprises about 8-14% water by weight and is substantially non-hygroscopic when exposed to atmosphere at a relative humidity of up to 40 to 60% at about 25° C.
2. The tartrate salt hydrate solid form of claim 1 wherein the solid form remains a solid upon standing in air at a relative humidity of 40-60% at 25° C. for a period of about 100 hours, or a period of about three months, or a period of about six months.
3. The tartrate hydrate solid form of claim 1 wherein the tartrate is the L form.