Local topical administration formulations containing indoxacarb
View Patent ↗The present invention provides formulations and methods useful in the control of ectoparasites on a domestic animal, using a formulation comprising Indoxacarb and a veterinarily acceptable carrier that is applied topically to 10% or less of the total surface area of a domestic animal. Other embodiments include these formulations also including one or more additional pesticides such as fipronil.
1. A local, topical, spot-on formulation for control of ectoparasites on a domestic animal comprising an ectoparasitically effective amount of Indoxacarb, a veterinarily acceptable carrier, and isopropyl alcohol; wherein the concentration of Indoxacarb in said formulation is at least 100 g/L; and wherein said veterinarily acceptable carrier comprises ethyl acetoacetate and triacetin.
2. The formulation of claim 1 , further comprising a pesticide in addition to Indoxacarb.
3. The formulation of claim 2 , wherein said pesticide is selected from the group consisting of insect growth regulator, organophosphate pesticide, carbamate pesticide, organochlorine pesticides, pyrethrin pesticide, pyrethroid pesticide, nicotine pesticide, neonicotinoid pesticide, copper-containing pesticide, anthelmintic agent, benzimidazole, salicylanilide, substituted phenol pesticide, pyrimidine pesticide, imidazothiazole pesticide, a Bacillus thuringensis toxin, chlorobenzilate, cyfluthrin, cypermethrin, dicofol, endosulfan, esfenvalerate, fenvalerate, lambda-cyhalothrin, methoxychlor, sulfur, cyclodiene, ryania, KT-199, and praziquantel.
4. The formulation of claim 2 , wherein said pesticide is a pyrethroid pesticide.
5. The formulation of claim 4 , wherein said pyrethroid pesticide is permethrin.
6. The formulation of claim 2 , wherein said pesticide is a phenylpyrazole.
7. The formulation of claim 6 , wherein said phenylpyrazole is fipronil.
8. The formulation of claim 1 , wherein said formulation comprises
15-25% Indoxacarb;
15-25% triacetin;
10-40% ethyl acetoacetate; and
QS isopropyl alcohol.
9. The formulation of claim 1 , wherein said formulation comprises
20% Indoxacarb;
20% triacetin;
25% ethyl acetoacetate; and
QS isopropyl alcohol.
10. The formulation of claim 1 , wherein said veterinarily acceptable carrier further comprises one or more of an adjuvant, co-solvent, colorant, surfactant, spreading oil, antioxidant, light stabilizer or tackifier.