Hydrophilic surfaces for reducing friction forces
View Patent ↗A substrate (for example an implantable medical device) is provided with a lubricious surface by grafting onto the surface monomers containing acrylamide groups and then hydrolyzing said groups under alkaline conditions, the grafting step being carried out in an aqueous environment.
1. A method of providing a substrate with a lubricious surface on only a part of the substrate, including the steps of grafting onto only the part of the substrate in an aqueous environment a monomer containing an acrylamide functional group and then hydrolysing said functional group in alkaline conditions in order further to increase the lubricious nature of said surface, wherein the part of the substrate which is not to be treated is masked with a non-reactive polymer which is removed at the end of the method, wherein the substrate is a medical device.
2. A method as claimed in claim 1 wherein the monomer is acrylamide or N-N dimethylacrylamide.
3. A method as claimed in claim 1 wherein prior to the grafting step the surface of the substrate is activated to increase adhesion of the polymer.
4. A method as claimed in claim 3 wherein the activation is carried out by means of a plasma treatment, corona discharge, ozone treatment or by chemical activation.
5. A method as claimed in claim 3 wherein the surface activation results in hydroxyl groups being formed at the surface of the substrate.
6. A method as claimed in claim 1 wherein the substrate is formed from a polyether block amide.
7. A method as claimed in claim 1 additionally comprising the step of attaching a bioactive to the hydrolysed functional group.
8. A method of providing a substrate with a lubricious surface, including the steps of masking a first part of the substrate with a non-reactive polymer, grafting onto only a second part of the substrate in an aqueous environment a monomer containing an acrylamide functional group, hydrolysing said functional group in alkaline conditions in order further to increase the lubricious nature of said surface, and then removing the non-reactive polymer, wherein the substrate is a medical device.
9. A method as claimed in claim 8 wherein the monomer is acrylamide or N-N dimethylacrylamide.
10. A method as claimed in claim 8 wherein prior to the grafting step the surface of the substrate is activated to increase adhesion of the polymer.
11. A method as claimed in claim 10 wherein the activation is carried out by means of a plasma treatment, corona discharge, ozone treatment or by chemical activation.
12. A method as claimed in claim 10 wherein the surface activation results in hydroxyl groups being formed at the surface of the substrate.
13. A method as claimed in claim 8 wherein the substrate is formed from a polyether block amide.
14. A method as claimed in claim 8 additionally comprising the step of attaching a bioactive to the hydrolysed functional group.