GLYCEROL LINKED PEGYLATED SUGARS AND GLYCOPEPTIDES

1 . A peptide conjugate comprising:

a) a peptide which is covalently attached to a moiety which is a member selected from:

in which R 2 is a member selected from H, CH 2 OR 7 , COOR 7 and OR 7 ,

wherein R 7 is a member selected from H, substituted or unsubstituted alkyl and substituted or unsubstituted heteroalkyl;

R 3 , R 4 , R 5 and R 6 are members independently selected from H, substituted or unsubstituted alkyl, OR 8 and NHC(O)R 9 ;

wherein R 8 and R 9 are independently selected from H, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, sialic acid and polysialic acid;

and wherein at least one of R 3 , R 4 , R 5 , R 6 includes a moiety which is a member selected from:

in which the indices m and n are integers independently selected from 1 to 1000;

A 1 , A 2 , A 3 , A 4 , A 5 , A 6 , A 7 , A 8 , A 9 , A 10 and A 11 are members independently selected from H, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, —NA 12 A 13 , —OA 12 and —SiA 12 A 13 ;

wherein

A 12 and A 13 are members independently selected from substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, and substituted or unsubstituted heteroaryl.

2 . The peptide conjugate of claim 1 , wherein said at least one of R 3 , R 4 , R 5 , R 6 includes a moiety which is a member selected from:

3 . The peptide conjugate of claim 1 , wherein said moiety is a member selected from:

4 . The peptide conjugate of claim 1 , wherein said peptide in the peptide conjugate is a member selected from bone morphogenetic protein 2 (BMP-2), bone morphogenetic protein 7 (BMP-7), bone morphogenetic protein 15 (BMP-15), neurotrophin-3 (NT-3), von Willebrand factor (vWF) protease, Factor VII, Factor VIa, Factor VIII, Factor IX, Factor X, Factor XI, B-domain deleted Factor VIII, vWF-Factor VIII fusion protein having full-length Factor VIII, vWF-Factor VIII fusion protein having B-domain deleted Factor VIII, erythropoietin (EPO), granulocyte colony stimulating factor (G-CSF), Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF), interferon alpha, interferon beta, interferon gamma, α 1 -antitrypsin (ATT, or α-1 protease inhibitor), glucocerebrosidase, Tissue-Type Plasminogen Activator (TPA), Interleukin-2 (IL-2), urokinase, human DNase, insulin, Hepatitis B surface protein (HbsAg), human growth hormone, TNF Receptor-IgG Fc region fusion protein (Enbrel™), anti-HER2 monoclonal antibody (Herceptin™), monoclonal antibody to Protein F of Respiratory Syncytial Virus (Synagis™), monoclonal antibody to TNF-α (Remicade™), monoclonal antibody to glycoprotein IIb/IIIa (Reopro™), monoclonal antibody to CD20 (Rituxan™), anti-thrombin III (AT III), human Chorionic Gonadotropin (hCG), alpha-galactosidase (Fabrazyme™), alpha-iduronidase (Aldurazyme™), follicle stimulating hormone, beta-glucosidase, anti-TNF-alpha monoclonal antibody, glucagon-like peptide-1 (GLP-1), glucagon-like peptide-2 (GLP-2), beta-glucosidase, alpha-galactosidase A and fibroblast growth factor