Compounds
The present invention provides compounds of formula (I): a process for their preparation, pharmaceutical compositions comprising the compounds and the preparation of said compositions, intermediates and use of the compounds for the manufacture of a medicament for therapeutic treatment, particularly for the treatment of inflammation, allergy and/or skin disease.
1. A compound of formula (I):
wherein
R 1 is thienyl or
R 2 is ethyl or n-propyl;
R 3 is hydrogen or methyl;
R 4 is hydrogen or fluorine;
R 5 and R 6 are each independently hydrogen, methyl, fluorine, chlorine or trifluoromethyl; or a salt thereof.
2. A compound according to claim 1 wherein R 1 is
3. A compound according to claim 1 wherein R 2 is ethyl.
4. A compound according to claim 1 wherein R 3 is hydrogen.
5. A compound according to claim 1 wherein R 4 is fluorine.
6. A compound according to claim 1 wherein R 5 is hydrogen and R 6 is methyl, fluorine or chlorine.
7. A compound according to claim 1 wherein R 5 and R 6 are both fluorine or both chlorine.
8. A compound which is selected from the group consisting of:
N-ethyl-2-methyl-N-[3,3,3-trifluoro-2-({[1-(4-fluorophenyl)-1H-indazol-4-yl]amino}methyl)-2-hydroxypropyl]benzamide;
N-ethyl-2-fluoro-N-[3,3,3-trifluoro-2-({[1-(4-fluorophenyl)-1H-indazol-4-yl]amino}methyl)-2-hydroxypropyl]benzamide;
2,6-dichloro-N-ethyl-N-[3,3,3-trifluoro-2-({[1-(4-fluorophenyl)-1H-indazol-4-yl]amino}methyl)-2-hydroxypropyl]benzamide; and a salt thereof.
9. A method of treating an inflammatory and/or allergic condition in a human or animal subject in need thereof, which method comprises administering to said human or animal subject an effective amount of a compound as claimed in claim 1 , or a pharmaceutically acceptable salt thereof.
10. A method of treating rheumatoid arthritis, asthma, COPD, allergy and/or rhinitis in a human or animal subject in need thereof, which method comprises administering to said human or animal subject an effective amount of a compound as claimed in claim 1 , or a pharmaceutically acceptable salt thereof.