MicroRNA (miRNA) for the diagnosis and treatment of heart diseases
View Patent ↗The invention relates to microRNAs (miRNAs) for the diagnosis, prophylaxis and/or treatment of heart diseases. It relates in particular to SEQ ID No: 1 to SEQ ID No: 29 for the diagnosis, prophylaxis and/or treatment of heart diseases. In addition, the invention relates to the use of these sequences to produce a medicament for heart diseases and for the diagnosis thereof. Also encompassed are a method for the diagnosis of a heart disease, a kit and an expression vector comprising these sequences, a cell which contains the expression vector, and also a method for modulating a heart disease and a method for screening a pharmaceutically active compound for the treatment and/or prophylaxis of a heart disease.
1. A method for treating a heart disease comprising inhibiting the expression or activity of SEQ ID NO: 14 in a human subject having heart disease with an oligonucleotide complementary to SEQ ID NO: 14, wherein the heart disease is selected from the group consisting of myocardial infarction, heart failure, chronic heart failure, and cardiac hypertrophy.
2. A method for treating a heart disease in a human subject having an increased expression level of miR-21 in the heart tissue of the subject, comprising inhibiting the expression or activity of SEQ ID NO: 14 in the human subject with an oligonucleotide complementary to SEQ ID NO: 14, wherein the heart disease is selected from the group consisting of myocardial infarction, heart failure, chronic heart failure, and cardiac hypertrophy.
3. The method of claim 1 , wherein the heart disease is myocardial infarction.
4. The method of claim 1 , wherein the heart disease is heart failure.
5. The method of claim 4 , wherein the heart failure is chronic heart failure.
6. The method of claim 1 , wherein the heart disease is cardiac hypertrophy.