Therapeutic agent for inflammatory bowel diseases
View Patent ↗The present invention relates to a method for maintaining the remission of or treating inflammatory bowel diseases, which comprises administering a maintenance therapeutically effective amount or a therapeutically effective amount of 7,8-dimethoxy-4(5H),10-dioxo-1H-1,2,3-triazolo[4,5-c][1]benzoazepine, a prodrug thereof, or a pharmaceutically acceptable salt thereof to a mammal, wherein the prodrug is 2-(1-isopropoxycarbonyloxy-2-methylpropyl)-7,8-dimethoxy-4(5H),10-dioxo-2H-1,2,3-triazolo[4,5-c][1]benzoazepine. The method according to the present invention is effective in the maintenance therapy and therapy of the inflammatory bowel diseases and has few side effects. Particularly, the method according to the present invention may exhibit strong maintenance therapeutic and therapeutic effects, even on severe cases having resistance to the conventional therapeutics.
1. A method for maintaining the remission of or treating inflammatory bowel diseases (IBD), which comprises administering a maintenance therapeutically effective amount or a therapeutically effective amount of 7,8-dimethoxy-4(5H),10-dioxo-1H-1,2,3-triazolo[4,5-c][1]benzoazepine, a prodrug thereof, or a pharmaceutically acceptable salt thereof to a mammal,
wherein the prodrug is 2-(1-isopropoxycarbonyloxy-2-methylpropyl)-7,8-dimethoxy-4(5H),10-dioxo-2H-1,2,3-triazolo[4,5-c][1]benzoazepine.
2. A method according to claim 1 , wherein the compound to be administered is 2-(1-isopropoxycarbonyloxy-2-methylpropyl)-7,8-dimethoxy-4(5H),10-dioxo-2H-1,2,3-triazolo[4,5-c][1]benzoazepine, or a pharmaceutically acceptable salt thereof.
3. A method according to claim 2 , wherein the administration is oral administration.
4. A method according to claim 2 , which comprises the administration of the effective amount of the compound together with a pharmaceutically acceptable carrier.
5. A method according to claim 2 , wherein the inflammatory bowel disease is ulcerative colitis or Crohn's disease.
6. A method according to claim 1 , wherein the administration is oral administration.
7. A method according to claim 1 , which comprises the administration of the effective amount of the compound together with a pharmaceutically acceptable carrier.
8. A method according to claim 1 , wherein the inflammatory bowel disease is ulcerative colitis or Crohn's disease.